首页|Praseodymium metal nanorods as a 5-fluorouracil carrier
Praseodymium metal nanorods as a 5-fluorouracil carrier
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Interest in metal nanoparticles as nanoscale drug-carrying vehicles has been increasing.In such an aspect,lanthanide metal nanoparticles are particularly intriguing.Herein,we report praseodymium nanoparticles as a novel anticancer therapeutic transporting agent.The material was made as a com-posite with the supramolecular host polymer,poly-β-cyclodextrin.The praseodymium nanorods were characterized using standard analytical techniques,including X-ray diffraction(XRD),X-ray photoelec-tron spectroscopy(XPS),and thermogravimetric analysis(TGA).In addition,they were imaged using transmission electron microscopy.The nanostructures are a long rod-shaped material with 2.0±0.1 μm in length and 230±10 nm in width.The material shows a saturation magnetization value above 30 emu/g with a coercivity value of 130 Oe.The nanocarrier is freighted with the drug 5-fluorouracil,and the encapsulation efficiency is 76.09％.The drug release is continuous from the nanocarrier(polymer-con-taining praseodymium nanoparticles)and proceeds for above 250 h.The in vitro cytotoxicities of the blank nanocarrier and the 5-fluorouracil-loaded one are deduced by testing them on MCF-7 and Vero(non-cancerous)cell lines.The cytotoxicity on the cancerous cell lines is observed,whereas the non-cancerous cells are unaffected.The IC50 values on the cell lines are reported.
Metal nanoparticlesPraseodymiumPoly-cyclodextrinDrug deliveryAnticancer activityRare earths
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