首页|Facile synthesis of a tumor microenvironment-responsive nanomaterial with metallic polyphenol-encapsulated for enhanced synergistic therapy
Facile synthesis of a tumor microenvironment-responsive nanomaterial with metallic polyphenol-encapsulated for enhanced synergistic therapy
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The tumor microenvironment(TME)differs from normal tissue cells in its physiological and biochemical characteristics.The construction of TME-responsive nanoplatforms requires a tedious preparation pro-cess and complex multicomponent modification.In this work,Er@EGCG-Cu,a TME-responsive nano-platform,was simply and rapidly synthesized by combining rare earth-doped nanomaterials(NaLuF4:Yb,Er)with EGCG-Cu which is based on the ability of metal ions to coordinate with polyphenols to form a metal-phenolic network(MPN)structure.The MPN structure is then destroyed under an acidic TME,releasing the chemotherapy(CT)drug EGCG,which can cause apoptosis.CuxSy is generated by combining Cu2+with H2S overexpressed in human colorectal cancer cells and can be used for photo-thermal therapy(PTT).Cell experiments show that laser irradiation improves the CT/PTT synergistic effect of Er@EGCG-Cu.This study has significance for the construction of TME-responsive nanomedicines with simple and rapid preparation for synergistic therapy.
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