失眠障碍患者睡眠脑电分型与治疗研究进展
Advances on sleep electroencephalogram in the subtyping and treatment of insomnia disorder
吕洞宾 1张毓 1苑成梅 1张天宏 1肖泽萍1
作者信息
- 1. 上海交通大学医学院附属精神卫生中心,上海 200030
- 折叠
摘要
失眠障碍是一种临床常见的精神障碍.目前失眠障碍的临床分型主要依据临床症状描述,缺乏客观检测依据,治疗循证基础薄弱.近年来,睡眠脑电对于观察患者睡眠结构和连续性的异常日益受到重视,有助于探索失眠障碍的生物机制,有利于临床精准分型并提升个性化治疗水平.本文着重综述失眠障碍的睡眠脑电亚型的五种分型,包括基于客观睡眠时间、功率频谱特征、循环交替模式、纺锤波和微觉醒的分型并说明各亚型与临床转归关联的特点,旨在为失眠障碍的临床分型和个性化治疗提供循证依据.
Abstract
Insomnia disorder is a common clinical mental disorder.Currently,clinical subtyping of insomnia disorder relies primarily on symptomatic descriptions,lacking objective measures and subtyping-based treatment approaches.In recent years,increasing attention has been drawn to sleep electroencephalo-graphy(EEG)as a valuable tool for observing abnormal sleep architecture and continuity of insomnia disor-der.Sleep EEG analysis holds the potential to elucidate the underlying biological mechanisms of insomnia disorder,facilitating data-driven subtyping and enhancing personalized therapeutic strategies.Five types of sleep EEG subtypes of insomnia disorder were systematically searched and summarized:classifications de-rived from objective sleep duration,power spectral characteristics,cyclic alternating pattern,spindle and mi-croarousal.EEG characteristics of each subtype and clinical outcomes are discussed.This review aims to pro-vide evidence-based insights for clinical subtyping and personalized treatment of insomnia disorder.
关键词
失眠障碍/睡眠脑电/睡眠结构/分型/治疗/转归结局Key words
Insomnia disorder/Sleep electroencephalogram/Sleep structure/Subtyping/Treatment/Outcome引用本文复制引用
基金项目
国家自然科学基金(81971261)
上海市申康发展中心重大临床研究项目(SHDC2020CR4074)
上海市科委科技创新行动计划(20Y11906600)
出版年
2024
NETL
NSTL
维普
万方数据