Research progress in reconsolidation-based interventions for aversive memories
Aversive memories are the core pathology of many psychiatric disorders(such as postt-raumatic stress disorder and depression),often impeding clinical treatment,which requires validated inter-ventions.Animal researches and preclinical human studies have shown that memories are vulnerable after re-trieval due to a memory process known as the memory reconsolidation mechanism,and that interventions dur-ing this process can potentially rewrite or update memories.The discovery of the reconsolidation mechanism has sparked a wave of research interest in its potential to rewrite aversive memories.This article presents a brief research history and advances in reconsolidation-based interventions,including pharmacological,non-in-vasive brain stimulation and behavioral interventions,as well as the biological mechanisms of reconsolidation.It is noted that pharmacological,behavioral and non-invasive brain stimulation interventions are all potential approaches for reconsolidation intervention,with propranolol,extinction/exposure therapy and transcranial magnetic stimulation being relatively effective.It is important to consider the differences between laboratory and clinical studies in future clinical translational research,and to overcome the"boundary conditions"of re-consolidation-based intervention in clinical applications,such as duration of memory retrieval,age of memory,individual differences,and so on,which may affect its efficacy.
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