Correlation between attempted suicide and childhood trauma and inflammatory cytokines levels in adolescents with depressive disorder
Objective To explore the correlation between attempted suicide and childhood trauma as well as inflammatory cytokines levels in adolescents with depressive disorder.Methods From January to December 2021,a total of 164 adolescents with depressive disorder were included and categorized into at-tempted suicide group(n=108)and non-attempted suicide group(n=56)according to whether they accom-panied attempted suicide or not.The Chinese version of the suicide module of MINI 5.0,the childhood trau-ma questionnaire(CTQ),and the center for epidemiological studies depression scale(CES-D)were used to assess suicidal behavior,childhood trauma and depressive symptoms,while the plasma inflammatory cytokines levels were measured by electrochemiluminescence technology.The data were statistically analyzed by SPSS 23.0 software.Logistic regression was applied to analyze the independent influencing factors of attempted suicide and the predictive value of each independent risk factor for attempted suicide was assessed by receiv-er operating characteristic curve(ROC)curves.Results The prevalence of attempted suicide was 65.9％(108/164)in adolescents with depressive disorder.The univariate analyses showed that the total CTQ score((55.19±12.44),(45.50±12.11))(t=-4.771,P＜0.001),CES-D total score((40.75±10.26),(32.98±13.39))(t=-4.131,P＜0.001),IL-6 level(1.87(1.32,2.69)pg/mL,1.56(1.05,1.87)pg/mL)(Z=-3.102,P=0.002),IL-10 level(0.53(0.38,0.83)pg/mL,0.47(0.31,0.69)pg/mL)(Z=-2.100,P=0.036)and IL-17A level(2.20(1.52,3.65)pg/mL,1.67(1.25,2.97)pg/mL)(Z=-2.254,P=0.024)in plasma of patients in the attempted suicide group were signifi-cantly higher than those in non-attempted suicide group.Logistic stepwise regression analyses showed that CTQ total score,IL-6,IL-10,and IL-17A were risk factors for attempted suicide in adolescents with depres-sive disorder.The ROC showed that the total score of CTQ combined with IL-6(AUC=0.782,95％CI=0.709-0.855,P＜0.001),the total score of CTQ combined with IL-10(AUC=0.765,95％CI=0.688-0.841,P＜0.001),and the total score of CTQ combined with IL-17A(AUC=0.762,95％CI=0.684-0.840,P＜0.001)had a larger area under the curve,indicating better recognition and prediction ability for attempted sui-cide,with high sensitivity and specificity.Conclusion The incidence of attempted suicide in adolescents with de-pressive disorder is high,and which is closely related to childhood trauma and the levels of inflammatory cytokines.
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