Effects of cortisol-awakening response on multi-target tracking in children with attention deficit hy-peractivity disorder:the mediating role of working memory
Objective To explore the mediating role of working memory(WM)in the cortisol-a-wakening response(CAR)and multiple object tracking(MOT)in children with attention deficit hyperactiv-ity disorder(ADHD).Methods 92 children with ADHD(ADHD group)and 94 typically developing chil-dren(control group)were selected from January 2022 to October 2022.Salivary cortisol levels were detected and analyzed in all children at four time points after awakening.Children's WM and MOT performance were assessed by the 1-back and MOT paradigms,respectively.SPSS 26.0 software was used for t-test and Pearson correlation analysis of the data,and plug-in PROCESS model 4 of SPSS 26.0 was used for mediated effects analysis.Results(1)ADHD group showed significantly lower CAR,1-back accuracy and MOT performance((30.97±5.63),(81.33±10.64)％,(2.36±0.37))than the control group((32.41±3.48),(91.19±7.12)％,(2.62±0.28))(t=-2.09,-7.22,-5.31,all P＜0.05).(2)Pearson analysis showed that CAR was positively correlated with 1-back accuracy(r=0.293,P＜0.01)and MOT performance(r=0.740,P＜0.01).1-back accuracy was positively correlated with MOT performance(r=0.368,P＜0.01).(3)WM partially mediated the effect of CAR on MOT in children with ADHD,accounting for 6.13％(0.003/0.049)of the total effect.Conclusion Children with ADHD have deficits in MOT.WM plays a mediating role between CAR and MOT performance in children with ADHD.
NETL
NSTL
万方数据
