Effects of microglia in the pathogenesis of major depressive disorder
Major depressive disorder(MDD)has become an increasingly serious public health is-sue,characterized by high incidence and high disability rates.It often coexists with other mental health prob-lems and physical diseases,with a significant negative impact on patients'quality of life.In clinical practice,MDD is considered a heterogeneous disease.The complexity of the pathological mechanisms and the variabil-ity in treatment responses lead to a lack of clear therapeutic targets,which complicates the treatment process.In recent years,with advancements in neuroscience,the crucial role of microglia in the pathogenesis of MDD has been revealed.As the main immune cells in the brain,microglia are not only involved in the regulation of neuroinflammation but also play important roles in neurogenesis and neuronal regulation in MDD.This article mainly discusses the role of microglia in the pathophysiological mechanisms of MDD,aiming to provide a the-oretical basis for microglia as a potential target for the treatment of MDD.
Major depressive disorderMicrogliaNeuronsNeuroinflammation
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