小胶质细胞在抑郁症发病机制中的作用
Effects of microglia in the pathogenesis of major depressive disorder
杨艳杰 1张计丽 1卜天一 1乔可欣 1邱晓惠 1乔正学 1王雨 1陈宇 1万博文 1徐梓航1
作者信息
- 1. 哈尔滨医科大学心理科学与健康管理中心,哈尔滨 150081
- 折叠
摘要
抑郁症已成为一个日益严重的公共健康问题,其发病率和致残率均较高,常与多种心理健康问题和躯体疾病共存,对患者的生活质量造成了显著的负面影响.在临床实践中,抑郁症被认为是一种具有异质性的疾病,病理机制的复杂性和治疗反应的差异性导致其缺乏明确的治疗靶标,进而使得治疗过程愈加复杂.近年来,随着神经科学的不断发展,研究揭示了小胶质细胞在抑郁症的发病机制中扮演着至关重要的角色.作为大脑中主要的免疫细胞,小胶质细胞在抑郁症发病机制中不仅涉及神经炎性反应的调节,还在神经发生以及神经元调控等方面发挥着关键作用,本文主要探讨了小胶质细胞在抑郁症病理生理学机制中的作用,旨在为小胶质细胞作为抑郁症潜在治疗靶点提供理论基础.
Abstract
Major depressive disorder(MDD)has become an increasingly serious public health is-sue,characterized by high incidence and high disability rates.It often coexists with other mental health prob-lems and physical diseases,with a significant negative impact on patients'quality of life.In clinical practice,MDD is considered a heterogeneous disease.The complexity of the pathological mechanisms and the variabil-ity in treatment responses lead to a lack of clear therapeutic targets,which complicates the treatment process.In recent years,with advancements in neuroscience,the crucial role of microglia in the pathogenesis of MDD has been revealed.As the main immune cells in the brain,microglia are not only involved in the regulation of neuroinflammation but also play important roles in neurogenesis and neuronal regulation in MDD.This article mainly discusses the role of microglia in the pathophysiological mechanisms of MDD,aiming to provide a the-oretical basis for microglia as a potential target for the treatment of MDD.
关键词
抑郁症/小胶质细胞/神经元/神经炎性反应Key words
Major depressive disorder/Microglia/Neurons/Neuroinflammation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据