Influencing factors of loss of follow-up in a cohort study of participants with acute phase depressive disorders
Objective To explore the influencing factors of loss of follow-up in a cohort study of participants with acute phase depressive disorders.Methods A multicenter prospective cohort of patients with depressive disorders conducted from 2017 to 2021 was followed up at baseline,week 4,and week 8.The general information,disease characteristics,life satisfaction,functional status and other information of the sub-jects were collected.Loss of follow-up was determined by whether the patients followed the follow-up plan for on-site visits.SAS 9.4 software was used for data description and statistical analysis,and multiple Logistic re-gression analysis was used to explore the influencing factors of subjects loss to follow-up.Results A total of 1 023 patients with acute phase depressive disorders were included in the study.The scores of the 17-item Hamilton depression rating scale,the quality of life enjoyment and satisfaction questionnaire-short form,and Sheehan disability scale were 18.3±6.6,37.7±9.6,and 13.8±7.5,respectively.The loss of follow-up ratios at week 4,week 8 and complete visits were 28.6％(293/1 023),19.5％(199/1 023),and 13.9％(142/1 023),respectively.Multivariate analysis showed that higher depression severity at baseline(OR=0.81,95％CI=0.79-0.84)and higher life satisfaction at baseline(OR=0.96,95％CI=0.95-0.97)were associated with lower loss of follow-up ratio at week 4.Compared with the＜30-year group,the loss of follow-up ratio at week 4 in the 40-49-year group was lower(OR=0.36,95％CI=0.19-0.65).Patients with high anxiety factor scores(OR=1.41,95％CI=1.30-1.54)and the first depressive episode(OR=1.52,95％CI=1.10-2.12)had higher loss of follow-up ratio at week 4.The lower loss of follow-up ratio was asso-ciated with education level at week 8(OR=0.42,95％CI=0.21-0.85)and life satisfaction at week 4(OR=0.97,95％CI=0.94-0.99).A higher baseline anxiety levels(OR=1.38,95％CI=1.27-1.50),lower severity of baseline depressive symptoms(OR=0.83,95％CI=0.80-0.86),younger age(OR=0.44,95％CI=0.25-0.75),and lower baseline life satisfaction(OR=0.96,95％CI=0.95-0.97)were associated with a higher risk of complete loss of follow-up.There was a significant association between the research cen-ter and the loss of follow-up rate at week 4,8,and complete visits.Conclusions Patients with first episode depression in the acute phase,younger onset age,lower depression severity,comorbid anxiety symptom,and poor or no improvement in disease-related quality of life/satisfaction were associated with a higher risk of loss of follow-up in the prospective cohort study.
Depressive disorderCohort studyLoss of follow-upAnxietyLife satisfac-tionInfluencing factor
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