环状RNA与认知功能障碍相关疾病
circular RNA and cognitive dysfunction related diseases
刘树齐 1邬鑫雨 2林佳槟 2殷盛明1
作者信息
- 1. 大连医科大学基础医学院,大连 116044
- 2. 大连医科大学附属第二医院,大连 116027
- 折叠
摘要
环状RNA(circular RNA,circRNA)广泛存在于真核生物中.在具有认知功能下降的动物模型和认知功能障碍的人群中,均发现特定circRNA表达异常,但其在认知功能障碍相关疾病中的作用尚不清楚.本综述重点介绍circRNA在认知功能相关脑区的表达、circRNA对脑结构和功能的影响、circRNA参与认知功能障碍相关疾病的病理发生机制的相关研究进展,以期为揭示circRNA在认知功能障碍相关疾病中的病理作用机制,发现防治认知功能障碍的特定circRNA靶点提供理论依据.
Abstract
Circular RNA(circRNA)is widely expressed in eukaryotes.Abnormal expression of specific circRNA was found in both animal models with cognitive decline and patients with cognitive dysfunc-tion.However,the role of circRNA in cognitive dysfunction related diseases is still unclear.By introducing the expression of circRNA in cognitive function related brain regions and its impact on brain structure and function,as well as the relevant research progress on the pathological mechanism of circRNA involvement in cognitive dysfunction related diseases,this review provides theoretical basis for revealing the pathological mechanism of circRNA in cognitive dysfunction related diseases and discovering specific circRNA targets for preventing and treating cognitive dysfunction.
关键词
环状RNA/微小RNA/认知功能/认知功能障碍/分子生物标志物Key words
Circular RNA/Micro RNA/Cognitive function/Cognitive dysfunction/Molec-ular biomarker引用本文复制引用
基金项目
大连医科大学大学生创新创业训练计划(X202210161102)
大连医科大学大学生创新创业训练计划(X202210161094)
出版年
2024
NETL
NSTL
万方数据