circular RNA and cognitive dysfunction related diseases
Circular RNA(circRNA)is widely expressed in eukaryotes.Abnormal expression of specific circRNA was found in both animal models with cognitive decline and patients with cognitive dysfunc-tion.However,the role of circRNA in cognitive dysfunction related diseases is still unclear.By introducing the expression of circRNA in cognitive function related brain regions and its impact on brain structure and function,as well as the relevant research progress on the pathological mechanism of circRNA involvement in cognitive dysfunction related diseases,this review provides theoretical basis for revealing the pathological mechanism of circRNA in cognitive dysfunction related diseases and discovering specific circRNA targets for preventing and treating cognitive dysfunction.
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