Application of chemogenetic technology in the study of neural circuits in depression
Chemogenetic technology is a receptor-ligand system that regulates cell viability and func-tion by changing receptor specificity and affinity,and it achieves precise neuronal regulation by specifically regulating neurons and neural circuits.At present,this technique is widely used in the study of neural cir-cuits.This article briefly describes the application and progress of chemogenetic technology in the study of depression neural circuits,reviews the application of chemogenetic technology in several brain regions closely related to depression,such as ventral tegmental area,nucleus accumbens,prefrontal cortex,hippocampus and lateral habenula,and discusses the potential and challenges of chemogenetic technology as a technology for precise regulation of neural activity in future research,in order to provide reliable ideas and directions for chemogenetic technology in the study of depression neural circuits.
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