青春期抑郁啮齿类动物模型的建立与评价
Establishment and evaluation of rodent animal model of adolescent depression
董涛 1李莹 2高耀 3刘鹏鸿 4刘志芬4
作者信息
- 1. 山西医科大学第一临床医学院,太原 030604
- 2. 山西医科大学医学科学院,太原 030604
- 3. 山西省人工智能辅助精神疾病诊疗重点实验室,山西医科大学第一医院,太原 030604
- 4. 山西医科大学第一医院精神卫生科,太原 030604
- 折叠
摘要
抑郁症是青少年最常见的精神障碍之一,具有高复发率、高自杀率的特点,严重危害青少年身心健康发展.青春期抑郁动物模型可以模拟人类抑郁表型,有助于研究疾病发病机制,寻找有效治疗靶点,开发新的抗抑郁药物.因此,为了筛选更符合实验要求的动物模型,本文回顾了青春期抑郁动物模型相关文章,全面汇总和分析了目前常用的青春期抑郁动物模型(应激模型、遗传模型、化学诱导模型、手术损伤模型以及复合模型)的建模方法和原理、优缺点及行为评价方式等,并展望青春期抑郁动物模型的发展方向,旨在更好地模拟疾病的发生发展情况,为青春期抑郁动物模型相关研究提供多种动物模型选择,为后续的研究奠定基础.
Abstract
Depression is one of the most common mental disorders in adolescents,with high recur-rence rate and high suicide rate,seriously endangering the physical and mental health development of adoles-cents.Adolescent depression animal models can mimic the human depression phenotype,which can help to study the disease pathogenesis,find effective therapeutic targets,and develop new antidepressant drugs.Therefore,in order to screen animal models that better meet the experimental requirements,this paper reviews the articles on animal models of adolescent depression,comprehensively summarises and analyses the model-ling methods and principles,strengths and weaknesses,and behavioural evaluations of the commonly used an-imal models of adolescent depression(stress models,genetic models,chemically-induced models,surgical in-jury models and composite models),and look forward to the development direction of animal models of de-pression in adolescence.It also looks forward to the development direction of adolescent depression animal models,aiming to better simulate the development of the disease,provide a variety of animal models for ado-lescent depression animal model related research,and lay the foundation for subsequent research.
关键词
青春期/抑郁症/动物模型/模型建立Key words
Adolescence/Depression/Animal model/Model establishment引用本文复制引用
基金项目
国家 自然科学基金(82171534)
中央引导地方科技发展资金项目(YDZJSX2022A063)
山西省科技创新人才团队专项资金(202204051001027)
出版年
2024
NETL
NSTL
万方数据