Establishment and evaluation of rodent animal model of adolescent depression
Depression is one of the most common mental disorders in adolescents,with high recur-rence rate and high suicide rate,seriously endangering the physical and mental health development of adoles-cents.Adolescent depression animal models can mimic the human depression phenotype,which can help to study the disease pathogenesis,find effective therapeutic targets,and develop new antidepressant drugs.Therefore,in order to screen animal models that better meet the experimental requirements,this paper reviews the articles on animal models of adolescent depression,comprehensively summarises and analyses the model-ling methods and principles,strengths and weaknesses,and behavioural evaluations of the commonly used an-imal models of adolescent depression(stress models,genetic models,chemically-induced models,surgical in-jury models and composite models),and look forward to the development direction of animal models of de-pression in adolescence.It also looks forward to the development direction of adolescent depression animal models,aiming to better simulate the development of the disease,provide a variety of animal models for ado-lescent depression animal model related research,and lay the foundation for subsequent research.
NETL
NSTL
万方数据
