Correlation between 1,5-anhydroglucitol and mild cognitive impairment in elderly patients with type 2 diabetes mellitus
Objective To explore the correlation between serum 1,5-anhydroglucitol(1,5-AG)and mild cognitive impairment(MCI)in elderly patients with type 2 diabetes mellitus(T2DM).Methods A total of 160 patients with T2DM aged 60-75 years old who visited the First Hospital of Hebei Medical University from May 2021 to July 2022 were selected.According to the Montreal cognitive assess-ment(MoCA),all patients were divided into T2DM with MCI group(T2DM+MCI group,n=81)and T2DM without MCI group(T2DM group,n=79).All research subjects were tested for glycated hemoglobin A1c(HbA1c),serum 1,5-AG,serum β-amyloid peptide 42(Aβ42),and blood biochemical indicators.SPSS 25.0 statistical software was used for data analysis.The t test,Mann-Whitney U test and x2 test were used to compare the two groups.Binary Logistic regression analysis was used to examine the relevant influen-cing factors.Results(1)Compared with T2DM group,patients in T2DM+MCI group had significantly higher age,systolic pressure and HbA1c(all P＜0.05).The level of 1,5-AG in T2DM+MCI group was signif-icantly lower than that in T2DM group((15.65±2.56)μg/mL,(18.17±3.72)µg/mL,P＜0.01),and the level of Aβ42 was higher than that of T2DM group(2.95(3.36)pg/mL,1.91(2.48)pg/mL,P＜0.05).(2)Binary Logistic regression analysis results showed that HbA1c(β=0.230,OR=1.259,95％CI=1.010-1.568,P=0.040)and Aβ42(β=0.188,OR=1.206,95％CI=1.033-1.409,P=0.018)were the independ-ent risk factors for MCI in elderly patients with T2DM,while 1,5-AG(β=-0.240,OR=0.786,95％CI=0.698-0.886,P＜0.001)was the protective factor for MCI.Conclusion There is a positive correlation be-tween serum 1,5-AG and cognitive function,and the decrease of 1,5-AG level was associated with the in-creased risk of MCI in elderly patients with T2DM.
Type 2 diabetes mellitus1,5-anhydroglucitolMild cognitive impairmentβ-amyloid peptide 42
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