摘要
抑郁障碍为儿童青少年群体常见的一种情感障碍,给心理社会发展带来严重的负面影响.然而现有医疗系统中儿童青少年抑郁的风险预测、诊断、治疗方案选择仍缺乏客观的指标.生物标志物作为反映生理状态的客观指标,对抑郁障碍的病理机制可提供重要信息.本文就目前已有的关于儿童青少年抑郁障碍的外周血生物标志物研究进行综述,并总结了其应用于临床的可行性.研究显示外周血中免疫、神经内分泌、神经营养、多层级组学相关物质与儿童青少年抑郁障碍的发生和严重程度可能存在重要关联,具体标志物的预测作用需要结合其他多模态数据,相关证据仍需更多大样本研究加以验证.
Abstract
Depressive disorder is a highly prevalent mood disorder among children and adolescents,which can exert profoundly negative impacts on psychosocial development.However,in the current medical system there still lacks objective indicators for the risk assessment,diagnosis and treatment selection of de-pression in this population.Biomarkers,which serve as objective indicators of physiological states,can offer crucial insights into pathological mechanisms of depressive disorders.This paper provides a comprehensive review of existing research on peripheral blood biomarkers associated with depression in children and adoles-cents,highlighting the feasibility of their clinical application.Studies indicate that substances in immune,neuroendocrine,neurotrophic,and multi-level omics system in peripheral blood can be significantly linked to the diagnosis and severity of depression in this population.Nevertheless,the predictive role of specific bio-markers necessitates integration with other multimodal data,and replication through studies with large sample size is needed.
基金项目
科技创新2030-"脑科学与类脑研究"重大项目(2022ZD0209105)
徐汇区卫生健康委员会重要疾病联合攻关项目(XHLHGG202106)
上海市加强公共卫生体系建设三年行动计划(2023-2025年)重点学科建设项目(GWVI-11.1-33)
NETL
NSTL
万方数据