Peripheral blood biomarkers in children and adolescents with depressive disorders
Depressive disorder is a highly prevalent mood disorder among children and adolescents,which can exert profoundly negative impacts on psychosocial development.However,in the current medical system there still lacks objective indicators for the risk assessment,diagnosis and treatment selection of de-pression in this population.Biomarkers,which serve as objective indicators of physiological states,can offer crucial insights into pathological mechanisms of depressive disorders.This paper provides a comprehensive review of existing research on peripheral blood biomarkers associated with depression in children and adoles-cents,highlighting the feasibility of their clinical application.Studies indicate that substances in immune,neuroendocrine,neurotrophic,and multi-level omics system in peripheral blood can be significantly linked to the diagnosis and severity of depression in this population.Nevertheless,the predictive role of specific bio-markers necessitates integration with other multimodal data,and replication through studies with large sample size is needed.
Children and adolescentsDepressive disorderPeripheral bloodBiomarkers
NETL
NSTL
万方数据
