Effects of levodopa on inhibitory control in patients with early-to-mid stage idiopathic Parkinson disease
Objective To explore the effect of levodopa on inhibitory control in Parkinson disease patients using the paced random number generation task(RNG).Methods The study included 47 patients diagnosed with Parkinson disease in the Movement Disorder Clinic of the Department of Neurology at Dalian Friendship Hospital between March 2020 and June 2022,and 45 healthy volunteers with normal cognitive function were recruited from the Physical Examination Center of the same hospital and matched in terms of age,gender and education.All subjects performed the paced RNG task twice within two days,converting the results into continuous number sequences measure values and random number sequences measure values.SPSS 22.0 software was used for statistical analysis,and mixed-design ANOVA was used to compare the per-formance of the two groups of subjects in the paced RNG task during medication/withdrawal.The minimum clinical importance difference(MCID)was calculated to evaluate whether statistically significant medication effects have clinical significance.Results(1)Medication and cognitive load had an interaction effect on the random number sequences measure values(F=15.15,P=0.03),which showed that the random number sequences measure values increased under on-medication status and slow rate(off-medication:(44.79±16.33),on-medication:(51.95±21.82);t=4.25,P=0.02),and the difference in the combined standard deviation of random digits seriation measurements between on-medication and off-medication at a slow rate(7.16)was greater than that of MCID(3.29).(2)The main effect of cognitive load on the continuous number sequences measure values was statistically significant(F=65.97,P＜0.001),and scores for rapid rate were higher(rapid:(71.45±37.98);slow:(36.33±16.17)).Conclusion Levodopa can improve in-hibitory cognitive control in patients with Parkinson disease under low cognitive load.
Parkinson diseaseExecutive functionInhibitory controlDopaminergicRan-dom number generation task
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