Muscle-brain crosstalk mechanisms in the cognitive-motor interference effects of freezing of gait in Parkinson disease
Freezing of gait is a common gait disorder in Parkinson disease(PD),which is highly disabling,situational and therapeutically challenging.At present,there is no clear and effective intervention method.In recent ten years,exercise training based on cognitive-motor dual tasks has been more and more used in the intervention treatment of freezing of gait of PD patients,and achieved certain clinical results.The muscle-brain crosstalk effect of exercise training promoting muscle secretory factors is crucial for freezing of gait rehabilitation of PD.There are differences in the effects of cognitive-motor dual tasks of different types and loads on gait,but the specific training types and loads and mechanism of action still need to be further e-lucidated.This paper focuses on the research progress of muscle-brain crosstalk mechanism in cognitive-mo-tor interference effect of freezing of gait in PD patients,aiming to providing a new theoretical perspective for clinical cognitive-motor training intervention of freezing of gait in PD patients.
Parkinson diseaseFreezing of gaitCognitive-motor interferenceDual tasksMyokine
NETL
NSTL
万方数据
