帕金森病冻结步态认知-运动干扰效应中的肌-脑串扰机制
Muscle-brain crosstalk mechanisms in the cognitive-motor interference effects of freezing of gait in Parkinson disease
李佩 1张霈竹 1王共强 2马心锋 3童广安 3林康 3金平3
作者信息
- 1. 安徽中医药大学研究生院,合肥 230012
- 2. 安徽中医药大学神经病学研究所,合肥 230038
- 3. 安徽中医药大学神经病学研究所附属医院,合肥 230061
- 折叠
摘要
冻结步态是帕金森病(Parkinson disease,PD)常见的、高致残、情境性、治疗上具有挑战性的一种步态障碍,目前尚缺少明确有效的干预手段.近十年来,基于认知-运动双任务的运动训练被越来越多地用于PD患者冻结步态的干预治疗,并取得一定的临床效果.运动训练促进肌肉分泌肌因子的肌-脑串扰作用对PD冻结步态认知-运动康复至关重要,不同类型和负荷的认知-运动双任务对步态的影响存在差异,但具体训练类型和负荷及作用机制仍需要进一步阐明.本文就PD患者冻结步态认知-运动干扰效应中肌-脑串扰机制研究进展进行归纳概括,旨在为PD患者冻结步态临床认知-运动训练干预提供新的理论视角.
Abstract
Freezing of gait is a common gait disorder in Parkinson disease(PD),which is highly disabling,situational and therapeutically challenging.At present,there is no clear and effective intervention method.In recent ten years,exercise training based on cognitive-motor dual tasks has been more and more used in the intervention treatment of freezing of gait of PD patients,and achieved certain clinical results.The muscle-brain crosstalk effect of exercise training promoting muscle secretory factors is crucial for freezing of gait rehabilitation of PD.There are differences in the effects of cognitive-motor dual tasks of different types and loads on gait,but the specific training types and loads and mechanism of action still need to be further e-lucidated.This paper focuses on the research progress of muscle-brain crosstalk mechanism in cognitive-mo-tor interference effect of freezing of gait in PD patients,aiming to providing a new theoretical perspective for clinical cognitive-motor training intervention of freezing of gait in PD patients.
关键词
帕金森病/冻结步态/认知-运动干扰/双任务/肌动蛋白Key words
Parkinson disease/Freezing of gait/Cognitive-motor interference/Dual tasks/Myokine引用本文复制引用
基金项目
安徽省高校自然科学研究基金重点项目(2023AH050793)
安徽中医药大学临床科研基金重大项目(2021sfylc04)
出版年
2024
NETL
NSTL
万方数据