As cerebellum is involved in sleep regulation,cerebellar dysfunction can lead to sleep disorders,and changes in cerebellar structure and function have also been observed in some patients with sleep disorders.However,the exact mechanism of cerebellum regulation of sleep is still unified.This review summarized the anatomical basis of cerebellar neuronal activity changes with sleep-wake cycle,the changes of cerebellar and brain connection circuits during sleep-wake cycle,the abnormal behaviors caused by cerebellar function/structure disorders,and the abnormal changes of cerebellar structure in patients with different sleep disorders.It is proposed that cerebellar is involved in regulating sleep,and there are different forms of sleep disorders in patients with cerebellar dysfunction.The structural and functional integrity of cerebellum are al-so affected by sleep,suggesting that there may be a causal relationship between cerebellar structural and functional abnormalities and sleep disorders.Based on the high plasticity of cerebellar neurons,the electro-physiological mechanisms of cerebellar involvement in sleep may be further explored by regulating the electri-cal activity of cerebellar neurons in the future,so as to verify the possibility of improving sleep disorders through cerebellar regulation.
NETL
NSTL
万方数据
