Necroptosis mediated by receptor-interacting serine/threonine-protein kinase 1 and Alzheimer's dis-ease
Alzheimer's disease(AD)is a refractory neurodegenerative disease clinically character-ized by memory loss and cognitive and behavioral dysfunction.The main pathological features of AD include neuronal loss,β-amyloid protein(Aβ)deposition and neurofibrillary tangles(NFTs),and numerous studies have shown that these may be triggered by neuronal death and neuroinflammation Receptor-interacting ser-ine/threonine-protein kinase 1(RIPK1)is a serine/threonine kinase present at the intersection of cell death and inflammatory signaling pathways.Studies in recent years have revealed a potential role of RIPK1 on the progress of AD.In this paper,we summarized the links between RIPKl-mediated necroptosis and AD treat-ment from the aspects of neuronal death,inflammasome activation,blood-brain barrier breakdown and mito-chondrial dysfunction,and the targeted treatment of RIPK1,the new findings of RIPK1 inhibitors and ongoing clinical trials,aiming to provide new ideas for the treatment of AD.
Alzheimer's diseaseNecroptosisReceptor interacting protein kinase 1
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