The effect of triglyceride-glucose index on the severity of depression in patients with depression
Objective To investigate the effect of triglyceride-glucose index(TyG)on the severity of depression in patients with depression.Methods The clinical data of 653 patients with depression admit-ted to Hebei General Hospital from January to December 2021 were retrospectively analyzed.The patients were categorized into mild-moderate depression group(n=324)and severe depression group(n=329)ac-cording to the 17-item Hamilton depression scale(HAMD-17)score.Patients'demographics and data on fasting plasma glucose(FPG),triglyceride(TG),total cholesterol,high-density lipoprotein,and low-density lipoprotein were extracted from the electronic medical records,and TyG was calculated.Statistical analyses were performed by SPSS 25.0 software.The Mann-Whitney U test was used to compare the differences be-tween the two groups.Spearman correlation analysis and binary Logistic regression analysis were used to in-vestigate the relationship between TyG level and depression severity.Results(1)In the severe depression group,FPG(956.9(118.9)mg/L vs 865.0(1 44.2)mg/L),TG(1 275.8(1 027.8)mg/L vs 983.5(766.4)mg/L),total cholesterol(2 007.0(477.6)mg/L vs 1 730.5(547.2)mg/L),high-density lipo-protein(514.3(168.2)mg/L vs 464.0(138.2)mg/L),low-density lipoprotein(1 264.5(326.8)mg/L vs 1 088.6(412.8)mg/L),and TyG(8.72(0.77)vs 8.37(0.78))were higher than those in the mild-moderate depression group,and the differences were statistically significant(all P＜0.05).(2)Both TyG level and HAMA score were positively correlated with HAMD-17 score(r=0.231,0.586,both P＜0.05);(3)The results of binary logistic regression analysis showed that TyG(B=1.116,OR=3.054,95％CI=2.058-4.531,P＜0.05)was a risk factor for the severity of depression in patients with depression.Conclu-sion The higher the TyG,the more severe the severity of depression in patients.Insulin resistance may af-fect the severity of depression in patients with depression.
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