Objective To investigate the clinical value of atherogenic index of plasma(AIP)on the occurrence of acute myocardial infarction(AMI)and evaluate its predictive value.Methods This was a prospective cohort study.A total of 98 875 employees of Kailuan Group Company who had no previous history of myocardial infarction from July 2006 to October 2007 were selected as the observation cohort and followed up until 31 December 2019.Baseline data was recorded and new AMI was used as the endpoint event.All participants were divided into four quartile groups according to the AIP.Q,group(n=24 560):AIP＜-0.56;Q2 group(n=24 925):-0.56≤AIP＜-0.16;Q3 group(n=24 653):-0.16≤AIP＜0.31;Q4 group(n=24 737):AIP ≥0.31.The cumulative incidence of myocardial infarction was calculated using the lifetime table method and compared between four groups using the log-rank test.Multivariate Cox regression was used to analyze the effect of AIP on the occurrence of AMI.Results A total of 1 804 study participants occurred AMI after the mean follow-up 12.9±1.0 years.With the increase of AIP quartile grouping,the cumulative incidence of AMI showed an increasing trend,1.23％,1.47％,2.11％and 2.47％in four groups respectively(P＜0.001).After adjusting for age,gender,educational level,physical exercise,family per capita monthly income,smoking,alcohol consumption,medical history of stroke,whether to take antihypertensive drugs,hypoglycemic drugs,systolic blood pressure,body mass index,total cholesterol,fasting blood glucose,blood uric acid,and C reactive protein,Cox regression analysis results showed that HR for AIP was 1.30(95％CI:1.21-1.41,P＜0.001),which meant one standard deviation increase by AIP(0.68),the risk of AMI was increased by 30％.Compared with the Q 1 group,the risk of AMI in the Q3 group and Q4 group increased 46％(HR=1.46,95％CI:1.24-1.71,P＜0.001)and 70％(HR=1.70,95％ CI:1.45-1.99,P＜0.001).However,the risk of AMI was not significantly increased in the Q2 group(HR=1.15,95％CI:0.97-1.35,P=0.11).Conclusions Data from the Kailuan cohort study shows that increased AIP is an independent risk factor for the occurrence of AMI.
关键词
急性心肌梗死/动脉粥样硬化/血浆致动脉粥样硬化指数/预测价值
Key words
Acute myocardial infarction/Atherosclerosis/Atherogenic index of plasma/Predictive value
维普
万方数据