Objective To evaluate the effect of neutrophil percentage/hemoglobin ratio(NPHR)on 1-year all-cause mortality in patients with severe chronic heart failure(CHF).Methods This was a retrospective study.A total of 622 patients with severe CHF admitted to the Department of Cardiology in Beijing Chaoyang Hospital affiliated to Capital Medical University from 2011 to 2016 were continuously enrolled.NPHR values within 24 hours of admission were collected,and patients were followed up by telephone and outpatient.The endpoint event was defined as 1-year all-cause mortality after discharge.According to the median NPHR,patients were divided into high NPHR group(≥53.8,312 cases)and low NPHR group(＜53.8,310 cases).The Kaplan-Meier curve was used to explore the effect of NPHR on 1-year all-cause mortality in patients with severe CHF and multivariate Cox proportional hazard regression model was used to verify the predictive value of NPHR.Receiver Operating Characteristic(ROC)curve was used to evaluate the predictive power of NPHR for 1-year all-cause mortality.Results During the follow-up period,622 patients were not lost to follow-up,and a total of 122 patients died,with a mortality rate of 19.6％;33 patients died in the low NPHR group,with a mortality rate of 10.6％;89 patients died in the high NPHR group,with a mortality rate of 28.5％.The Kaplan-Meier curve showed that 1-year all-cause mortality in the high NPHR group was significantly higher than that in the low NPHR group(x2=31.24,P＜0.001).Multivariate Cox regression analysis found that high NPHR was an independent predictor of 1-year all-cause mortality(HR=1.03,95％CI:1.01～1.04,P=0.001).ROC curve analysis showed that,NPHR could predict 1-year all-cause mortality,and the area under an ROC curve was 0.697,the optimal cutoff was 56.07,with sensitivity of 69.7％and specificity of 63.8％(P＜0.001).Conclusions Admission NPHR is significantly associated with and may be an independent predictor of 1-year all-cause mortality in patients with severe CHF.
维普
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