主支药物洗脱支架+分支药物涂层球囊术式治疗真性分叉病变患者的临床预后
Clinical prognosis of the drug-eluting stent in main branch and drug-coated balloon in side branch procedure for the treatment of true bifurcation lesions
刘文 1魏芳晶2
作者信息
- 1. 010050 呼和浩特,内蒙古医科大学附属医院重症医学科
- 2. 010050 呼和浩特,内蒙古医科大学附属医院心血管内科
- 折叠
摘要
目的 探究主支药物洗脱支架(DES)+分支药物涂层球囊(DCB)术式治疗真性分叉病变患者的有效性和安全性,以及DCB治疗分叉病变的临床预后.方法 单中心、回顾性研究.连续纳入2019年3月至2021年6月于内蒙古医科大学附属医院接受经皮冠状动脉介入治疗且诊断为真性分叉病变的患者131例.依据接受术式不同将其分组:被动球囊拘禁组43例、主动球囊拘禁组43例和主支DES+分支DCB组45例.比较术后6个月随访时各组的血管晚期管腔丢失,以及术后12个月内各组的主要不良心血管事件(MACE)发生率.结果 术后6个月随访时,三组主支血管的晚期管腔丢失比较,差异无统计学意义(P=0.107);而主支DES+分支DCB组分支血管的晚期管腔丢失均低于其他两组(均为P＜0.05).术后12个月随访时,MACE发生率分别为主动球囊拘禁组16.3％、被动球囊拘禁组18.6％和主支DES+分支DCB组4.4％,三组间比较差异无统计学意义(P=0.107).与普通球囊组(主动球囊拘禁组+被动球囊拘禁组)相比,主支DES+分支DCB组的MACE发生率显著降低(4.4％比17.4％,P=0.036).结论 主支DES+分支DCB术式治疗真性分叉病变时,可有效改善患者预后,使用DCB治疗分叉病变可取得良好的临床预后.
Abstract
Objective To investigate the efficacy and safety of the drug-eluting stent(DES)in main branch and drug-coated balloon(DCB)in side branch procedure for the treatment of patients with true bifurcation lesions and the clinical prognosis of DCB for bifurcation lesions.Methods This was a single-center,retrospective study.It consecutively included 131 patients who underwent percutaneous coronary intervention and were diagnosed with true bifurcation lesions from March 2019 to June 2021 at the Affiliated Hospital of Inner Mongolia Medical University.Patients were divided into three groups based on the procedural technique used:43 patients in the jailed-balloon technique group,43 in the modified jailed-balloon technique group,and 45 in the main branch DES+side branch DCB group.Late lumen loss of the vessel was compared among the groups at 6-month follow-up and the incidence of major adverse cardiovascular events(MACE)in each group at 12 months postoperatively.Results At the 6-month postoperative follow-up,the late lumen loss of the main branch vessel in the three groups was not statistically significant(P=0.107);whereas the late lumen loss of the branch vessel in the main branch DES+side branch DCB group was lower than that of the other two groups(both P＜0.05).At the 12-month postoperative follow-up,the incidence of MACE was 16.3％in the modified jailed-balloon technique group,18.6％in the jailed-balloon technique group,and 4.4％in the main branch DES+side branch DCB group,with no statistically significant differences among the three groups(P=0.107).However,the incidence of MACE was significantly lower in the main branch DES+side branch DCB group compared to the normal balloon group(modified jailed-balloon technique group+jailed-balloon technique group)at 4.4％vs.17.4％(P=0.036).Conclusions The DES in main branch and DCB in side branch procedure effectively improve patients outcomes when treating true bifurcation lesions,and the use of DCB for bifurcation lesions can lead to favorable clinical prognosis.
关键词
冠状动脉真性分叉病变/经皮冠状动脉介入治疗/主动球囊拘禁技术/被动球囊拘禁技术/药物涂层球囊Key words
True bifurcation lesions of the coronary arteries/Percutaneous coronary intervention/Modified jailed-balloon technique/Jailed-balloon technique/Drug-coated balloons引用本文复制引用
基金项目
内蒙古自治区高等学校科学技术研究项目(NJZZ21033)
出版年
2024
NETL
NSTL
万方数据