Obesity cardiomyopathy is a metabolic cardiopathy caused by obesity and is closely related to mitophagy.Mitophagy is an important mitochondrial quality control,and FUN14 domain containing 1(FUNDC1),a mitochondrial outer membrane protein,plays a significant role in this process.In this article,we review the recent advances in the role of FUNDC1-mediated mitochondrial autophagy in the pathogenesis of obesity cardiomyopathy,aiming to provide new insights for the clinical treatment of the disease.
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