Lipoprotein(a)[Lp(a)]is an independent risk factor for various cardiovascular diseases.In recent years,the standardization of Lp(a)measurements and the development of drugs to lowering Lp(a)have garnered significant attention from researchers worldwide.This article provides a comprehensive review of Lp(a)from biochemistry,measurement and standardization,clinical applications,and the progress of drugs for lowering Lp(a)levels.The aim is to enhance understanding of Lp(a)and to serve as a reference for further research on the relationship between Lp(a)and cardiovascular diseases.