Correlations of TyG index,TyG-BMI index and TG/HDL-C ratio with the severity of coronary artery lesion in postmenopausal women with non-ST segment elevation acute coronary syndrome
Correlations of TyG index,TyG-BMI index and TG/HDL-C ratio with the severity of coronary artery lesion in postmenopausal women with non-ST segment elevation acute coronary syndrome
Objective To analyze and compare the relationships between TyG index,TyG-BMI index,TG/HDL-C ratio and Gensini score in postmenopausal femalenon-ST elevation acute coronary syndrome(NSTE-ACS)patients.Methods This retrospective study included a total of 489 postmenopausal female patients diagnosed with NSTE-ACS at the Department of Cardiovascular Medicine,First Affiliated Hospital of Jinzhou Medical University,from October 2021 to October 2023.The average age of the patients was 66.0±7.3 years.Based on the median Gensini score,the patients were categorized into two groups:low Gensini score group(score＜32 points,n=241)and high Gensini score group(score≥32 points,n=248).Additionally,patients were subdivided according to their chronic disease status into diabetes subgroup(n=138),hypertension subgroup(n=322),NSTEMI subgroup(n=141),and UA subgroup(n=348).Clinical data of all patients were collected and compared.Single-factor and multi-factor binary logistic regression analyses were employed to investigate the correlations of TyG index,TyG-BMI index,and TG/HDL-C ratio with the Gensini score,alongside subgroup analyses.The receiver operating characteristic(ROC)curve was utilized to evaluate and compare the predictive capabilities of the three indicators regarding the severity of coronary artery disease.Furthermore,Spearman rank correlation analysis was conducted to assess the linear relationships between the three indicators and the Gensini score.Results Multivariate logistic regression analysis revealed that TyG index(OR=2.879,P=0.002)and TG/HDL-C ratio(OR=1.168,P=0.005)are independent risk factors for Gensini score ≥32 points.Notably,TyG index remains an independent risk factor for a Gensini score≥32 points across various subgroups,including diabetes subgroup(OR=3.121,P=0.001),hypertension subgroup(OR=3.120,P＜0.001),NSTEMI subgroup(OR=3.622,P=0.006),and UA subgroup(OR=2.728,P＜0.001).The predictive ability of TyG index for Gensini score ≥32 points is superior to that of TyG-BMI index(P＜0.05);the difference in predictive ability compared to TG/HDL-C ratio is not statistically significant(P＞0.05).The TyG index(r=0.436),TyG-BMI index(r=0.170),and TG/HDL-C ratio(r=0.406)all demonstrated a linear positive correlation with Gensini score(all P＜0.001).The correlation of TyG index with Gensini score is comparable to that of TG/HDL-C ratio,both of which are stronger than the correlation exhibited by TyG-BMI index.Conclusions In postmenopausal female patients with NSTE-ACS,TyG index and TG/HDL-C ratio are identified as independent risk factors for the extent of coronary artery disease.The predictive capabilities of TyG index and TG/HDL-C ratio for Gensini score 32 points or higher,as well as their correlations with the Gensini score,are comparable.The relationship between TyG-BMI index and the degree of coronary artery disease warrants further investigation.
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