中国心血管杂志2024,Vol.29Issue(6) :579-584.DOI:10.3969/j.issn.1007-5410.2024.06.014

内皮细胞来源的外泌体及其调控的线粒体功能变化在心血管疾病中的研究进展

Research progress on endothelial exosomes and mitochondrial dysfunction in cardiovascular diseases

唐婷 路旭阳 焦凯 马雅楠 刘德敏
中国心血管杂志2024,Vol.29Issue(6) :579-584.DOI:10.3969/j.issn.1007-5410.2024.06.014

内皮细胞来源的外泌体及其调控的线粒体功能变化在心血管疾病中的研究进展

Research progress on endothelial exosomes and mitochondrial dysfunction in cardiovascular diseases

唐婷 1路旭阳 1焦凯 1马雅楠 1刘德敏1
扫码查看

作者信息

  • 1. 050000 石家庄,河北医科大学第二医院心内一科
  • 折叠

摘要

心血管疾病是导致人类死亡的主要原因之一.内皮细胞释放的外泌体通过信号传导传递其携带的生物分子,从而影响心血管疾病进程.线粒体作为细胞动力源,当其出现功能障碍时会导致多种心血管疾病的发生.本文主要从内皮细胞来源的外泌体对心血管疾病的影响,以及其调控的线粒体功能变化在心血管疾病模型中所发挥的作用等方面进行综述.

Abstract

Cardiovascular disease is one of the leading causes of death in humans.The exosomes released by endothelial cells transmit the biomolecules and influence the course of cardiovascular disease through signal transduction.Mitochondria as the power source of cells,when dysfunction,will lead to ATP production disorders and a variety of cardiovascular diseases.This article reviews the recent progress of exosomes and mitochondrial functions in cardiovascular diseases from the aspects of the effects of exosomes derived from endothelial cells on cardiovascular diseases and the role of mitochondrial functions regulated by exosomes in cardiovascular disease models.

关键词

心血管疾病/内皮细胞/外泌体/线粒体功能障碍

Key words

Cardiovascular disease/Endothelial cells/Exosomes/Mitochondrial dysfunction

引用本文复制引用

出版年

2024
中国心血管杂志
卫生部北京医院,天津医科大学

中国心血管杂志

CSTPCD北大核心
影响因子:0.993
ISSN:1007-5410
段落导航相关论文