血清HSP70、sICAM-1、CEA水平联合检测对卵巢囊肿患者术后复发的预测价值
Prognostic Value of Serum HSP70,sICAM-1 and CEA Levels in Postoperative Recurrence of Ovarian Cysts
杨艳 1杨少平 1王玉珍1
作者信息
- 1. 河南省淇县妇幼保健计划生育服务中心,河南 淇县 456750
- 折叠
摘要
目的 探讨血清热休克蛋白70(HSP70)、可溶性细胞间黏附分子-1(sICAM-1)、癌胚抗原(CEA)水平联合检测对卵巢囊肿患者术后复发的预测价值.方法 选取2020年1月—2022年1月行卵巢囊肿手术的60 例患者为研究对象,根据术后是否复发分为复发组(n=20)和非复发组(n=40),比较两组患者的一般资料、术前血清HSP70、sICAM-1、CEA水平,分析其与卵巢囊肿术后复发的相关性以及AUC指标.结果 复发组患者的年龄、囊肿直径、囊肿类型、恶性程度、术前血清HSP70水平均高于非复发组,差异有统计学意义(P＜0.05).单因素Logistic回归分析显示,年龄、BMI、囊肿直径、血清HSP70、sICAM-1、CEA水平是卵巢囊肿复发的危险因素(P＜0.05).多因素Logistic回归分析显示,血清HSP70是卵巢囊肿复发的独立危险因素(P＜0.05),而sICAM-1和CEA水平与卵巢囊肿复发无显著相关性(P＞0.05).联合检测对卵巢囊肿复发的预测能力优于单个指标.结论 血清HSP70、sICAM-1、CEA水平联合检测对卵巢囊肿患者术后复发具有一定的预测价值,其中HSP70可能是较为重要的预测指标.
Abstract
Objective To investigate the predictive value of serum heat shock protein 70(HSP70),soluble intercellular adhesion molecule-1(sICAM-1)and carcinoembryonic antigen(CEA)levels in postoperative recurrence in patients with ovarian cysts.Methods 60 patients who underwent ovarian cyst surgery from January 2020 to January 2022 were selected as the study objects,and were divided into recurrent group(n=20)and non-recurrent group(n=40)according to whether they had recurrence after surgery.General data,preoperative serum HSP70,sICAM-1 and CEA levels of the two groups were compared.Correlation with postoperative recurrence of ovarian cyst and AUC index were analyzed.Results Age,cyst diameter,cyst type,malignant degree,preoperative serum HSP70,sICAM-1 and CEA levels in the recurrent group were higher than those in the non-recurrent group,with statistical significance(P＜0.05).Univariate Logistic regression analysis showed that age,BMI,cyst diameter,serum HSP70,sICAM-1 and CEA levels were risk factors for ovarian cyst recurrence(P＜0.05).Multivariate Logistic regression analysis showed that serum HSP70 was an independent risk factor for recurrent ovarian cysts(P＜0.05),while sICAM-1 and CEA lecels were not significantly correlated with ovarian cyst recurrence(P＞0.05).The ability of combined detection to predict the recurrence of ovarian cyst is better than that of single index.Conclusion Combined detection of serum HSP70,sICAM-1 and CEA levels has certain predictive value for postoperative recurrence in patients with ovarian cysts,and HSP70 may be an important predictor.
关键词
卵巢囊肿/术后复发/HSP70/sICAM-1/CEAKey words
ovarian cyst/postoperative recurrence/HSP70/sICAM-1/CEA引用本文复制引用
出版年
2024
NETL
NSTL
万方数据