特发性膜性肾病伴高尿酸血症的临床病理特征及相关因素分析
Clinicopathological Features and Related Factors of Idiopathic Membranous Nephropathy with Hyperuricemia
曹裴扬 1乔青 1吴声 1王倩 1胡楠1
作者信息
- 1. 苏州大学附属第四医院,苏州市独墅湖医院肾内科,江苏 苏州 215123
- 折叠
摘要
目的 研究特发性膜性肾病(idiopathic membranous nephropathy,IMN)中高尿酸血症(hyperuricemia,HUA)患者的临床病理特征及相关危险因素.方法 回顾性分析苏州大学附属第四医院2020年1月—2024年4月经肾活检确诊为IMN患者75 例,收集患者的临床资料及病理资料.根据血尿酸水平分为高尿酸血症组(n=23)和正常尿酸组(n=52),分析两组患者的临床及病理学资料的特点,并分析HUA在IMN患者中的相关危险因素.结果 IMN患者中HUA的患病率为30.7%,血清白蛋白、甘油三酯、25羟维生素D、24 h尿蛋白定量在高尿酸血症组及正常尿酸组差异有统计学意义(P＜0.05).单因素Logistic分析结果显示,较高的白蛋白、甘油三酯、24 h尿蛋白定量以及较低的25羟维生素D水平是IMN患者HUA的危险因素.多因素Logistic回归分析显示,在IMN患者中,较高的白蛋白水平、24 h尿蛋白定量以及较低的25羟维生素D水平是导致HUA的独立危险因素.结论 在IMN患者中,HUA的发病率较高,积极控制尿酸及体重、积极治疗IMN以及补充维生素D可能对改善肾脏预后具有一定的积极作用.
Abstract
Objective To study the clinical and pathological features and related risk factors of hyperuricemia(HUA)in patients with idiopathic membranous nephropathy(IMN).Methods A retrospective analysis was conducted on 75 patients diagnosed with IMN through renal biopsy at the Fourth Affiliated Hospital of Soochow University from January 2020 to June 2024.Clinical and pathological data of the patients were collected.Patients were divided into two groups based on their serum uric acid levels:the hyperuricemia group(n=23)and the normal uric acid group(n=52).The clinical and pathological characteristics of the two groups were analyzed,and risk factors for HUA in IMN patients were identified.Results The prevalence of HUA in IMN patients was 30.7%.There were statistically significant differences(P＜0.05)between the hyperuricemia group and the normal uric acid group in serum albumin,triglycerides,25-hydroxyvitamin D,and 24-hour urine protein quantification.Univariate Logistic analysis showed that higher levels of albumin,triglycerides,and 24-hour urine protein quantification,along with lower levels of 25-hydroxyvitamin D,were risk factors for HUA in IMN patients.Multivariate Logistic regression analysis indicated that higher levels of albumin and 24-hour urine protein quantification,as well as lower levels of 25-hydroxyvitamin D,were independent risk factors for HUA in IMN patients.Conclusion The prevalence of HUA is relatively high in IMN patients.Actively controlling uric acid and body weight,treating IMN,and supplementing vitamin D may have positive effects on improving renal prognosis.
关键词
特发性膜性肾病/高尿酸血症/危险因素Key words
idiopathic membranous nephropathy/hyperuricemia/risk factors引用本文复制引用
出版年
2024
NETL
NSTL
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