摘要
目的 比较糖皮质激素5日疗法与10日疗法治疗慢阻肺的疗效及对D-二聚体、凝血酶原时间、血气指标的影响.方法 选择2021年1月—2023年12月在鲁山县人民医院接受治疗的86 例慢阻肺急性加重患者,依据治疗方法分为A组(n=43)、B组(n=43).B组患者应用糖皮质激素10日疗法治疗,B组患者应用糖皮质激素5日疗法治疗.对比两组患者治疗效果、呼吸困难程度(mMRC评分)、CAT问卷评分、D-二聚体、凝血酶原时间、血气指标[二氧化碳分压(PaCO2)、动脉氧分压(PaO2)]、不良反应.结果 两组患者治疗有效率比较差异无统计学意义(P＞0.05);比较两组患者治疗前后的mMRC评分、CAT问卷评分、D-二聚体、凝血酶原时间、血气指标,差异均有统计学意义(P＜0.05),而两组患者的上述指标差异无统计学意义(P＞0.05);B组患者不良反应发生率低于A组(P＜0.05).结论 糖皮质激素5日疗法、10日疗法治疗慢阻肺的疗效相当,均能改善患者的D-二聚体、凝血酶原时间、血气指标,缓解临床症状,而5日疗法不良反应更少,更值得临床推广.
Abstract
Objective To compare the efficacy of glucocorticoid 5-day therapy and 10-day therapy for COPD and its effects on D-dimer,prothrombin time and blood gas index.Methods 86 patients with acute exacerbation of COPD treated in Lushan People's Hospital from January 2021 to December 2023 were divided into group A(n=43)and group B(n=43)according to the treatment methods.Patients in group A were treated with 10-day glucocorticoid therapy,and patients in group B were treated with 5-day glucocorticoid therapy.The treatment effect,degree of dyspnea(mMRC score),CAT questionnaire score,D-dimer,prothrombin time,blood gas index[carbon dioxide partial pressure(PaCO2),arterial oxygen partial pressure(PaO2)],and adverse reactions were compared between the two groups.Results There was no difference in the treatment response rate(P＞0.05).After treatment,mMRC score,CAT questionnaire score,D-dimer,prothrombin time and blood gas indexes of the two groups wese significantly different from those before treatment(P＜0.05),but these was no significant difference between the two groups(P＞0.05).The incidence of adverse reactions in group B was lower than that in group A(P＜0.05).Conclusion The efficacy of corticosteroid 5-day therapy and 10-day therapy in COPD is comparable,which can improve D-dimer,prothrombin time,blood gas indexes,and relieve clinical symptoms,while 5-day therapy has fewer adverse reactions,which is more worthy of clinical promotion.
NETL
NSTL
万方数据