摘要
目的 探讨胎膜早破孕妇血清白细胞介素-22受体1(IL-22 R1)、可溶性细胞间黏附分子1(sICAM-1)、γ干扰素诱导蛋白16(IFI16)变化及临床意义.方法 选取2021年7月—2023年7月南阳市中心医院收治的72 例胎膜早破孕妇作为研究对象.将上述研究对象作为胎膜早破组(n=72),另选同期72 例正常健康足月分娩孕妇作为健康对照组(n=72).比较胎膜早破组与健康对照组孕妇的IL-22 R1、sICAM-1、IFI16水平.按照是否合并绒毛羊膜炎将胎膜早破组孕妇分为感染组(n=42)与未感染组(n=30).比较感染组与未感染组孕妇的IL-22 R1、sICAM-1、IFI16水平.绘制受试者工作特征(ROC)曲线分析IL-22 R1、sICAM-1、IFI16诊断胎膜早破孕妇是否合并绒毛羊膜炎的敏感度、特异度.结果 胎膜早破组孕妇的IL-22 R1、sICAM-1、IFI16水平均高于健康对照组孕妇(P＜0.05);感染组孕妇的IL-22 R1、sICAM-1、IFI16水平均高于未感染组孕妇(P＜0.05);ROC曲线分析显示,IL-22 R1诊断胎膜早破孕妇是否合并绒毛羊膜腔感染的曲线下面积(AUC)、敏感度、特异度分别为0.725、61.90%、76.67%;sICAM-1诊断胎膜早破孕妇是否合并绒毛羊膜腔感染的AUC、敏感度、特异度分别为0.795、73.81%、83.33%;IFI16诊断胎膜早破孕妇是否合并绒毛羊膜腔感染的AUC、敏感度、特异度分别为0.744、83.33%、63.33%.结论 胎膜早破孕妇IL-22 R1、sICAM-1、IFI16呈现出高水平表达,IL-22 R1、sICAM-1、IFI16水平对预测绒毛羊膜炎有一定临床意义.
Abstract
Objective To investigate the changes and clinical significance of serum interleukin-22 receptor 1(IL-22 R1),soluble intercellular adhesion molecule-1(sICAM-1)and γ-interferon-induced protein 16(IFI16)in pregnant women with premature rupture of membranes.Methods 72 pregnant women with premature rupture of membranes treated in Nanyang Central Hospital from July 2021 to July 2023 were selected as the study objects.These subjects were selected as the premature rupture group(n=72),and 72 normal healthy pregnant women with full-term delivery were selected as the healthy control group(n=72).The levels of IL-22 R1,sICAM-1 and IFI16 were compared between the premature rupture group and the healthy control group.Pregnant women with premature rupture of membranes were divided into infected group(n=42)and uninfected group(n=30)according to whether they were complicated with villous amniotic infection or not.The levels of IL-22 R1,sICAM-1 and IFI16 were compared between infected and uninfected pregnant women.Receiver operating characteristic(ROC)curve was drawn to analyze the sensitivity and specificity of IL-22 R1,sICAM-1 and IFI16 in the diagnosis of chorioamnitis in pregnant women with premature rupture of membranes.Results The levels of IL-22 R1,sICAM-1 and IFI16 in premature rupture group were higher than those in healthy control group(P＜0.05).The levels of IL-22 R1,sICAM-1 and IFI16 in infected pregnant women were higher than those in uninfected pregnant women(P＜0.05).ROC curve analysis showed that the area under the curve(AUC),sensitivity and specificity of IL-22 R1 in the diagnosis of villo-amniotic cavity infection in pregnant women with premature rupture of membranes were 0.725,61.90%and 76.67%,respectively.The AUC,sensitivity and specificity of sICAM-1 were 0.795,73.81%and 83.33%,respectively,in the diagnosis of villo-amniotic cavity infection in pregnant women with premature rupture of membranes.The AUC,sensitivity and specificity of IFI16 were 0.744,83.33%and 63.33%,respectively,in the diagnosis of villo-amniotic cavity infection in pregnant women with premature rupture of membranes.Conclusion IL-22R1,sICAM-1 and IFI16 are expressed at high levels in pregnant women with premature rupture of membranes.The levels of IL-22R1,sICAM-1 and IFI16 have certain clinical significance in predicting villi amnitis.
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