多发性骨髓瘤患者凝血指标的变化分析
Changes of Coagulation Indicators in Patients with Multiple Myeloma
苏建虹 1胡俊琳 1阙庆和1
作者信息
- 1. 龙岩市第一医院检验科,福建 龙岩 364000
- 折叠
摘要
目的 回顾性分析血栓四项和凝血七项检测在预测多发性骨髓瘤(MM)患者病情变化、血栓形成中的临床意义.方法 回顾性分析2022年1月—2023年12月就诊于苏州大学附属第一医院的MM患者100 例设为MM组,以及同时期来院体检的健康人100 名作为对照组.检测所有研究对象的血栓四项和凝血结果,其中包括纤溶酶-α2纤溶酶抑制剂复合物(PIC)、凝血酶-抗凝血酶复合物(TAT)、血栓调节蛋白(TM)、组织型纤溶酶原激活物-纤溶酶原激活物抑制剂1复合物(t-PAIC)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、D-二聚体(D-D)、纤维蛋白原(Fib)、纤维蛋白原降解产物(FDP)及抗凝血酶Ⅲ(AT-Ⅲ),用于分析检测结果与患者病情及预后的关系.结果与对照组相比较,MM组AT-Ⅲ检测结果减低,血栓四项和其余凝血检测结果均不同程度地高于对照组,差异有统计学意义(P＜0.05).MM患者不同免疫球蛋白分型间的比较显示:轻链组TT相对较低,Fib明显升高;IgG患者TM、D-D较IgA型和轻链组相对较高,IgA及IgG型患者更易出现凝血紊乱(P＜0.05).结论 对于MM患者血栓四项和凝血七项检测具有重要意义,可以根据凝血指标变化对病人病情变化进行早期的预判,从而为患者争取足够的时间来运用抗凝药物预防血栓的形成,为患者治疗及预后进行指导.
Abstract
Objective To retrospectively analyze the clinical significance of four items of thrombosis and seven items of coagulation detection in predicting disease changes and thrombosis in patients with multiple myeloma(MM).Methods A retrospective analysis was conducted on 100 patients with MM who were treated at the First Affiliated Hospital of Soochow University from January 2022 to December 2023 and were set as the MM group.At the same time,100 healthy people who came to the hospital for physical examination were used as the control group.The four items of thrombosis and coagulation results of all research subjects were detected,including plasmin-α2 plasmin inhibitor complex(PIC),thrombin-antithrombin complex(TAT),thrombomodulin(TM),tissue plasminogen activator-plasminogen activator inhibitor 1 complex(t-PAIC),prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),D-dimer(D-D),fibrinogen degradation products(FDP),fibrinogen(Fib)and antithrombin Ⅲ(AT-Ⅲ).These were used to analyze the relationship between the detection results and the patient's condition and prognosis.Results Compared with the control group,the detection result of AT-Ⅲ in the MM group was decreased,and the four items of thrombosis and other coagulation detection results were all higher than those of the control group to varying degrees,and the difference was statistically significant(P＜0.05).The comparison among different immunoglobulin types of MM patients showed that TT of the light chain group was relatively low,and Fib was significantly increased;TM and D-D of IgG patients were relatively higher than those of IgA type and light chain group.Patients with IgA and IgG types were more prone to coagulation disorders(P＜0.05).Conclusion The detection of four items of thrombosis and seven items of coagulation is of great significance for patients with MM.The changes in patients'conditions can be predicted early according to the changes in coagulation indicators,so as to gain enough time for patients to use anticoagulant drugs to prevent thrombosis and guide the treatment and prognosis of patients.
关键词
多发性骨髓瘤/血栓四项/凝血七项检测Key words
multiple myeloma/four items of thrombosis/seven items of coagulation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据