术前血清CRP/Alb、CA19-9检测对原发性肝癌切除术后复发的预测价值
Predictive Value of Preoperative Serum CRP/Alb and CA19-9 for Recurrence of Primary Liver Cancer after Resection
李雪 1潘栋婉 1陈影1
作者信息
- 1. 郑州陇海妇产医院检验科,河南 郑州 450000
- 折叠
摘要
目的 探讨术前血清C反应蛋白/白蛋白(CRP/Alb)比值、糖类抗原19-9(CA19-9)检测对原发性肝癌切除术后复发的预测价值.方法 回顾性分析郑州陇海妇产医院2021年3月—2023年5月收治的94 例行肝癌切除术原发性肝癌患者的临床资料,根据其术后6个月有无复发情况将其分为复发组31 例和未复发组63 例;对比复发组与未复发组患者CRP/Alb及CA19-9;采用Logistic分析影响原发性肝癌患者术后复发的相关因素;制作受试者工作特征曲线(ROC),分析血清CRP/Alb、CA19-9对原发性肝癌患者术后复发的预测价值.结果 两组患者性别、年龄、体质量指数(BMI)、病程、肿瘤直径、肿瘤数目、肿瘤分期、分化程度对比,差异无统计学意义(P＞0.05),复发组患者发生微血管侵犯占比高于未复发组(P＜0.05);复发组患者术前CRP、CRP/Alb及CA19-9水平高于未复发组,Alb水平低于未复发组(P＜0.05);Logistic回归分析,发现发生微血管侵犯、CRP/Alb及CA19-9升高为原发性肝癌患者根治术后复发的危险因素,OR为2.081、2.054、1.319;ROC分析显示,血清CRP/Alb、CA19-9及两者联合对原发性肝癌患者术后复发预测的曲线下面积(AUC)分别为0.831、0.843、0.956.结论 发生微血管侵犯、CRP/Alb及CA19-9升高为原发性肝癌患者根治术后复发的危险因素,CRP/Alb及CA19-9两者联合对原发性肝癌患者术后复发的预测价值较高.
Abstract
Objective To explore the predictive value of preoperative serum C-reactive protein/albumin(CRP/Alb)ratio and carbohydrate antigen 19-9(CA19-9)in the recurrence of primary liver cancer after resection.Methods The clinical data of 94 patients with primary liver cancer who underwent hepatectomy in Zhengzhou Longhai Obstetrics and Gynecology Hospital from March 2021 to May 2023 were analyzed retrospectively.According to the reccurrence of 6 months after operation,they were divided into recurrent group(n=31)and non-recurrent group(n=63).CRP/Alb and CA19-9 were compared between recurrent group and non-recurrent group.Logistic was used to analyze the related factors affecting postoperative recurrence of primary liver cancer.The receiver operating characteristic curve(ROC)was made to analyze the predictive value of serum CRP/Alb and CA19-9 in postoperative recurrence of patients with primary liver cancer.Results There was no significant difference in sex,age,body mass index(BMI),course of disease,tumor diameter,tumor number,tumor stage and degree of differentiation between the two groups(P＞0.05).The incidence of microvascular invasion in the recurrent group was higher than that in the non-recurrent group(P＜0.05).The levels of CRP,CRP/Alb and CA19-9 in the recurrent group were higher than those in the non-recurrent group,and the level of Alb in the recurrent group was lower than that in the non-recurrent group(P＜0.05).Logistic regression analysis showed that microvascular invasion,elevated CRP/Alb and CA19-9 were risk factors for recurrence in patients with primary liver cancer after radical resection.OR was 2.081,2.054 and 1.319.The area under the curve(AUC)of serum CRP/Alb,CA19-9 and their combination for postoperative recurrence in patients with primary liver cancer were 0.831,0.843 and 0.956,respectively.Conclusion Microvascular invasion and the increase of CRP/Alb and CA19-9 are the risk factors of recurrence in patients with primary liver cancer after radical resection.The combination of CRP/Alb and CA19-9 is of high value in predicting postoperative recurrence of primary liver cancer.
关键词
血清C反应蛋白/白蛋白比值/肝癌/原发性肝癌切除术/术后复发/预测价值Key words
serum C-reactive protein/albumin ratio/liver cancer/resection of primary liver cancer/postoperative recurrence/predictive value引用本文复制引用
出版年
2024
NETL
NSTL
万方数据