Objective To investigate the predictive effect of serum bone metabolism markers on refracture in patients with osteoporotic vertebral compression fractures(OVCF)undergoing percutaneous kyphoplasty(PKP).Methods 80 OVCF patients who underwent PKP in First Affiliated Hospital of Soochow University from 2020 to 2021 were selected as the research subjects.The clinical data of the patients,including age,gender,BMI,BMD and bone metabolism markers(TPINP,CROSSL,25OHD),were collected.The patients were divided into a refracture group(n=32)and a non-refracture group(n=48)according to whether refracture occurred 12 months after PKP.Results There was no significant difference in BMD between the non-fracture group and the refracture group 12 months after surgery(P＞0.05).The serum TPINP and 25OHD levels in the refracture group were lower than those in the non-fracture group,and the serum CROSSL level in the refracture group was higher than that in the non-fracture group(P＜0.05).Multivariate analysis showed that serum bone metabolism markers(TPINP,CROSSL,25OHD)were independent risk factors for recurrent fractures.The occurrence of re-fractures was negatively correlated with the concentrations of serum TPINP and 25OHD(P=0.012,P=0.021),and positively correlated with the concentration of serum CROSSL(P=0.006).Conclusion Monitoring the changes in the concentrations of serum bone metabolism markers(TPINP,CROSSL,25OHD)in patients after PKP surgery can predict the risk of re-fractures early and provide timely intervention measures to avoid the occurrence of re-fractures.
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