中国血液流变学杂志2024,Vol.33Issue(3) :359-362,371.DOI:10.3969/j.issn.1009-881X.2024.03.005

依达拉奉结合银杏叶提取物注射液对缺血性脑血管病的血脂、血液流变学指标的影响

Effects of Edaravone Combined with Ginkgo Biloba Extract Injection on Hemorheological Indexes and Lipid Indexes in Ischemic Cerebrovascular Diseases

张芳 田凤臣 马国军 张顺清
中国血液流变学杂志2024,Vol.33Issue(3) :359-362,371.DOI:10.3969/j.issn.1009-881X.2024.03.005

依达拉奉结合银杏叶提取物注射液对缺血性脑血管病的血脂、血液流变学指标的影响

Effects of Edaravone Combined with Ginkgo Biloba Extract Injection on Hemorheological Indexes and Lipid Indexes in Ischemic Cerebrovascular Diseases

张芳 1田凤臣 1马国军 1张顺清1
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作者信息

  • 1. 濮阳市第三人民医院神经内科,河南 濮阳 457000
  • 折叠

摘要

目的 分析依达拉奉结合银杏叶提取物注射液对缺血性脑血管病(ICVD)的影响.方法 将2022年1月—2023年12月120 例ICVD患者作为研究对象,按随机数字表法将其分为2组,每组60 例,对照组予以依达拉奉单独治疗,观察组则予以依达拉奉结合银杏叶提取物注射液治疗,采用美国国立卫生研究院卒中量表(NIHSS)对患者病情状况进行评估,并分析2组全血低切黏度(LBV)、全血高切黏度(HBV)、血浆黏度(PV)、总胆固醇(TC)、甘油三酯(TG)指标以及不良反应总发生率.结果 治疗后观察组PV、LBV、HBV指标明显低于对照组(P<0.05);治疗后观察组TG、TC指标明显低于对照组(P<0.05);治疗后观察组NIHSS评分明显低于对照组(P<0.05);观察组、对照组不良反应总发生率分别为3.33%、5.00%,2组不良反应比较差异无统计学意义(P>0.05).结论 ICVD患者实施依达拉奉结合银杏叶提取物注射液治疗临床疗效较佳,能够降低血脂、血液流变学指标,改善神经功能缺损状况,且安全性高.

Abstract

Objective To analyze the effects of Edaravone combined with Ginkgo Biloba extract injection on ischemic cerebrovascular disease(ICVD).Methods 120 ICVD patients from January 2022 to December 2023 were divided into 2 groups according to random number table method,with 60 cases in each group.The control group was treated with Edaravone alone,and the observation group was treated with Edaravone combined with Ginkgo Biloba extract injection.The National Institutes of Health Stroke Scale(NIHSS)was used to evaluate the disease status of the patients,and the indexes of whole blood low shear viscosity(LBV),whole blood high shear viscosity(HBV),plasma viscosity(PV),total cholesterol(TC),triacylglycerol(TG)and the total incidence of adverse reactions in the 2 groups were analyzed.Results After treatment,the indexes of PV,LBV and HBV in observation group were significantly lower than those in control group(P<0.05).After treatment,TG and TC indexes in observation group were significantly lower than those in control group(P<0.05).After treatment,NIHSS score in observation group was significantly lower than that in control group(P<0.05).The total incidence of adverse reactions in observation group and control group was 3.33%and 5.00%,respectively,and there was no statistical significance in adverse reactions between the two groups(P>0.05).Conclusion The clinical efficacy of Edaravone combined with Ginkgo Biloba extract injection in ICVD patients is better,which can reduce hemorheological indexes and lipid indexes,improve neurological deficits,and has high safety.

关键词

依达拉奉/银杏叶提取物注射液/缺血性脑血管病/血脂/血液流变学指标

Key words

Edaravone/Ginkgo Biloba extract injection/ischemic cerebrovascular disease/lipid index/hemorheological index

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出版年

2024
中国血液流变学杂志
中国生物医学工程学会,苏州大学

中国血液流变学杂志

影响因子:0.391
ISSN:1009-881X
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