Objective To investigate the effects of Haemosiderophon combined with Tirofiban treatment on clinical efficacy,inflammatory factors and hemorheological indexes in cerebral infarction.Methods Clinical data of 81 patients with cerebral infarction admitted to Zhoukou Dongxin Hospital from February 2021 to January 2024 were retrospectively analyzed and divided into the control group(Haemosiderophon treatment,n=39)and the experimental group(Haemosiderophon combined with Tirofiban treatment,n=42)according to the treatment plan.Clinical efficacy,inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],hemorheological indexes[fibrinogen(FIB),plasma viscosity(PV),red blood cell aggregation index(RAI)]and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group(90.46%)was significantly higher than that of the control group(74.36%)(P＜0.05).The levels of IL-6 and TNF-α decreased in both groups after treatment,and were lower in the experimental group(P＜0.05).FIB,PV and RAI were reduced in both groups after treatment and were lower in the experimental group(P＜0.05).The incidence of adverse reactions was 14.29%(6/42)in the experimental group and 10.26%(4/39)in the control group,and there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Haemosiderophon combined with Tirofiban improves clinical outcomes,inflammatory factors and hemorheological indexes levels in patients with cerebral infarction,and has a safety profile.
关键词
血塞通/替罗非班/脑梗死/临床疗效/炎性因子/血液流变学指标
Key words
Haemosiderin/Tirofiban/cerebral infarction/clinical efficacy/inflammatory factors/hemorheological index
维普
万方数据