Effects of Rivaroxaban Combined with Clopidogrel on Adverse Cardiovascular and Cerebrovascular Events and Coagulation Function in Patients with Atrial Fibrillation after PCI
Effects of Rivaroxaban Combined with Clopidogrel on Adverse Cardiovascular and Cerebrovascular Events and Coagulation Function in Patients with Atrial Fibrillation after PCI
Objective To analyze the effect of Rivaroxaban combined with Clopidogrel on adverse cardiovascular and cerebrovascular events and coagulation function in patients with atrial fibrillation(AF)after percutaneous coronary intervention(PCI).Methods 117 AF patients admitted to Rehabilitation Hospital of Xuchang Central Hospital from January 2021 to January 2023 were selected.All patients received PCI treatment.According to the difference in drug treatment after PCI,the patients were divided into a control group(59 cases,Warfarin+Clopidogrel treatment)and an observation group(58 cases,Rivaroxaban+Clopidogrel treatment).The adverse cardiovascular and cerebrovascular events,bleeding events,changes in coagulation function and drug safety were compared between the two groups.Results The main adverse cardiovascular and cerebrovascular events in the two groups were myocardial infarction and ischemic stroke.There was no significant difference in the total incidence of adverse cardiovascular and cerebrovascular events between the control group and the observation group(6.78%vs 3.45%,P＞0.05).The total incidence of bleeding events in the observation group was 6.90%(4/58),which was lower than that in the control group(P＜0.05).During the treatment,there was no TIMI major bleeding in the observation group,and there was 1 case of hemorrhagic stroke in the control group.At 6 and 12 months after treatment,the levels of APTT,PT and FiB in the observation group were higher than those in the control group(P＜0.05).The total incidence of adverse reactions in the observation group(5.17%)was lower than that in the control group(11.86%),but there was no statistically significant difference between the two groups(P＞0.05).Conclusion Compared with Warfarin and Clopidogrel,Rivaroxaban combined with Clopidogrel in the treatment of patients with AF after PCI has better anticoagulant effect,lower risk of bleeding,and acceptable safety.
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