中国血液流变学杂志2024，Vol.33Issue(3) ：466-469,封3.DOI:10.3969/j.issn.1009-881X.2024.03.028

血清UA、Cr及血浆ALB水平与双相情感障碍抑郁发作患者认知功能的关系研究

Relationship between Serum UA,Cr and Plasma ALB Levels and Cognitive Function in Patients with Bipolar Depressive Episode

吕琳 张彦华 邱玉海
中国血液流变学杂志2024，Vol.33Issue(3) ：466-469,封3.DOI:10.3969/j.issn.1009-881X.2024.03.028
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  • 万方数据

血清UA、Cr及血浆ALB水平与双相情感障碍抑郁发作患者认知功能的关系研究

Relationship between Serum UA,Cr and Plasma ALB Levels and Cognitive Function in Patients with Bipolar Depressive Episode

吕琳 1张彦华 2邱玉海1
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作者信息

  • 1. 南阳市第四人民医院检验科,河南 南阳 473003
  • 2. 南阳市第四人民医院心身医学科(精神十科),河南 南阳 473003
  • 折叠

摘要

目的 探讨血清尿酸(UA)、肌酐(Cr)及血浆白蛋白(ALB)水平与双相情感障碍抑郁发作患者认知功能的关系.方法 回顾性纳入2021年3月—2023年3月南阳市第四人民医院68 例双相情感障碍抑郁发作患者临床资料,患者入院时均采用蒙特利尔认知评估量表(MOCA)评定认知功能,并依据评估结果分为认知功能障碍组与认知功能正常组,对比两组基线资料及血清UA、Cr、血浆ALB水平,采用点二列相关性分析上述三项指标对患者认知功能的相关性,绘制受试者工作特征(ROC)曲线分析预测价值.结果 68 例双相情感障碍患者中认知功能障碍41 例,认知功能正常27 例;认知功能障碍组血清UA、Cr水平比对照组高,血浆ALB水平比对照组低(t=5.030、4.929、5.264,P＜0.05);经点二列相关性分析,结果显示血清UA、Cr与双相情感障碍抑郁发作患者发生认知功能障碍呈正相关(r=0.526、0.519,P＜0.05);血浆ALB与双相情感障碍抑郁发作患者发生认知功能障碍呈负相关(r=-0.544,P＜0.05);绘制ROC曲线,结果显示,血清UA、Cr、血浆ALB预测双相情感障碍抑郁发作患者认知功能障碍的AUC=0.818、0.808、0.819,并联检测的AUC=0.874,均具有一定预测价值.结论 血清UA、Cr、血浆ALB水平与双相情感障碍抑郁发作患者认知功能密切相关,观察三者水平变化有助于预测认知功能障碍发生情况.

Abstract

Objective To explore the relationship between the levels of serum uric acid(UA),creatinine(Cr)and plasma albumin(ALB)and cognitive function of patients with bipolar disorder.Methods Clinical data of 68 patients with depressive episode of bipolar disorder in Nanyang Fourth People's Hospital from March 2021 to March 2023 were retrospectively included.The cognitive function of patients was assessed by Montreal Cognitive Assessment Scale(MOCA)when they were admitted to hospital,and they were divided into cognitive impairment group and normal cognitive function group according to the evaluation results.The baseline data,serum UA,Cr and plasma ALB levels of the two groups were compared,and the correlation between the above three indexes and patients'cognitive function was analyzed by point-and-column correlation,and the predictive value of receiver operating characteristic(ROC)curve analysis was drawn.Results Among 68 patients with bipolar disorder,41 cases have cognitive dysfunction and 27 cases have normal cognitive function.The serum UA and Cr levels in the cognitive impairment group were higher than those in the control group,and the plasma ALB level was lower than that in the control group(t=5.030,4.929,5.264,P＜0.05).The results showed that serum UA and Cr were positively correlated with cognitive dysfunction in patients with bipolar disorder(r=0.526,0.519,P＜0.05).There was a negative correlation between plasma ALB and cognitive dysfunction in patients with bipolar disorder(r=-0.544,P＜0.05).The ROC curve was drawn.The results showed that serum UA,Cr and plasma ALB had certain predictive value in predicting cognitive dysfunction in patients with bipolar disorder,with AUC=0.818,0.808 and 0.819,and AUC=0.874 in parallel detection.Conclusion Serum UA,Cr and plasma ALB levels are closely related to cognitive function of patients with bipolar disorder.Observing the changes of these three levels is helpful to predict the occurrence of cognitive dysfunction.

关键词

双相情感障碍抑郁发作/尿酸/肌酐/白蛋白/认知功能

Key words

depressive episode of bipolar disorder/uric acid/creatinine/albumin/cognitive function

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出版年

2024
中国血液流变学杂志
中国生物医学工程学会,苏州大学

中国血液流变学杂志

影响因子：0.391
ISSN：1009-881X
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