Effect of Restrictive Transfusion Therapy on Clinical Outcome,Coagulation Function and Blatchford Score in Patients with Acute Upper Gastrointestinal Bleeding
Effect of Restrictive Transfusion Therapy on Clinical Outcome,Coagulation Function and Blatchford Score in Patients with Acute Upper Gastrointestinal Bleeding
Objective To investigate the effect of restrictive transfusion therapy on clinical outcome,coagulation function and Blatchford score in patients with acute upper gastrointestinal bleeding.Methods 118 patients with acute upper gastrointestinal haemorrhage admitted to Puyang People's Hospital between March 2022 and March 2024 were selected for the study,and were divided into a control group(treated with open blood transfusion,n=58)and an observation group(treated with restrictive blood transfusion,n=60)according to the difference in treatment methods.Clinical efficacy,clinical indexes,coagulation function[fibrinogen(FIB),activated partial thromboplatin time(APTT),thrombin time(TT),prothrombin time(PT)],Blatchford score,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group(88.33%)was significantly higher than that of the control group(72.41%)(P＜0.05).The time of symptom disappearance and hospitalization time of the observation group was shorter than that of the control group,and the Blatchford score was lower than that of the control group(P＜0.05).After treatment,FIB levels increased and APTT,TT and PT levels decreased in the two groups.FIB levels in the observation group were higher than those in the control group,and APTT,TT and PT levels were lower than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group was 5.00%(3/60),and the incidence of adverse reactions in the control group was 12.07%(7/58).Conclusion Restrictive transfusion therapy improves the clinical outcome of patients with acute upper gastrointestinal haemorrhage,improves coagulation function,Blatchford score and is safe.
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