Objective To compare the value of diffusion tensor imaging(DTI)and arterial spin labeling(ASL)in the assessment of renal graft fibrosis.Methods The study included 62 renal transplant recipients who underwent DTI,ASL and biopsy.Based on the differences in the degree of fibrosis of the transplanted kidneys as revealed by biopsies,patients were divided into 4 groups:ci0,ci1,ci2,and ci3.medullary and cortical apparent diffusion coefficients(ADC),fractional anisotropy(FA),and renal blood flow(RBF)were computed,and one-way analysis of variance was used to compare the differences in functional MRI parameters between the different fibrotic subgroups.The area under the receiver operating characteristic curve(AUC)was calculated to assess diagnostic performance.Spearman correlation coefficients were calculated to explore the relationship between functional MRI parameters and fibrosis.Results The RBF value in the ci0 group was higher than that in the ci2 group and the ci3 group.The medullary ADC values in ci2 and ci3 groups were lower than those in ci0 group,and the medullary ADC values in ci3 group were lower than those in ci1 group.ci1,ci2 and ci3 group had lower medullary FA values than the ci0 group.ci3 group had lower medullary FA values than the ci1 group.DTI had a higher AUC than ASL for identifying renal graft fibrosis,but the results were not statistically significant.The combined use of ASL and DTI helped to improve diagnostic efficacy compared to ASL alone.Conclusion DTI have higher diagnostic efficacy in non-invasively identifying the extent of fibrosis in renal grafts compare to ASL.The combined use of ASL and DTI contributes to improve diagnostic performance compared with ASL alone.
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