中国血液流变学杂志2024,Vol.33Issue(3) :494-498.DOI:10.3969/j.issn.1009-881X.2024.03.034

间充质干细胞在免疫性血小板减少症的研究和应用

Research and Application of Mesenchymal Stem Cells in Immune Thrombocytopenic Purpura

徐路尧 黄佳倩 毛旭华
中国血液流变学杂志2024,Vol.33Issue(3) :494-498.DOI:10.3969/j.issn.1009-881X.2024.03.034

间充质干细胞在免疫性血小板减少症的研究和应用

Research and Application of Mesenchymal Stem Cells in Immune Thrombocytopenic Purpura

徐路尧 1黄佳倩 2毛旭华3
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作者信息

  • 1. 苏州市科普事业发展服务中心,江苏 苏州 215006
  • 2. 苏州大学基础医学与生物科学学院生物化学与分子生物学系,江苏 苏州 215127
  • 3. 江苏大学附属宜兴医院医学检验科,江苏 宜兴 214200
  • 折叠

摘要

免疫性血小板减少症(immune thrombocytopenic purpura,ITP)是一种以血小板数量减少,出血性疾病风险增加为特征的自身免疫性疾病.ITP病理生理机制复杂,使用皮质类固醇、免疫抑制剂等药物治疗方法虽然有效,但存在不良反应和无法治愈等弊端.间充质干细胞(mesenchymal stem cells,MSCs)因其独特的免疫调节能力,被用于治疗多种自身免疫性疾病.近年来,越来越多的研究证实,MSCs在ITP的治疗中发挥重要作用.对此,该文综述了MSCs在ITP治疗中的研究进展,探讨其治疗潜力及未来研究方向.

Abstract

Immune thrombocytopenic purpura(ITP)is an autoimmune disorder characterized by reduced platelet counts and an increased risk of hemorrhagic conditions.The pathophysiology of ITP is complex,and while corticosteroids and immunosuppressants are effective in managing the symptoms,these treatments can lead to adverse reactions and are not curative.Mesenchymal stem cells(MSCs),known for their unique immunomodulatory capabilities,have been employed in the treatment of various autoimmune diseases.Recent studies have underscored the significant role of MSCs in the therapeutic landscape of ITP.This review summarizes the latest research on the application of MSCs in treating ITP,discussing their therapeutic potential and future research directions.

关键词

间充质干细胞/免疫性血小板减少症/细胞治疗

Key words

mesenchymal stem cells/immune thrombocytopenic purpura/cell therapy

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出版年

2024
中国血液流变学杂志
中国生物医学工程学会,苏州大学

中国血液流变学杂志

影响因子:0.391
ISSN:1009-881X
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