利拉鲁肽与甘精胰岛素治疗2型糖尿病的疗效比较
Efficacy comparison between liraglutide and insulin glargine in treatment of type 2 diabetic patients
曲庚汝 1姜莉莉 1吴军1
作者信息
- 1. 青岛市海慈医疗集团,山东青岛 266033
- 折叠
摘要
目的 观察应用利拉鲁肽与甘精胰岛素治疗2型糖尿病患者的疗效和安全性.方法 60例口服二甲双胍和磺脲类药物血糖控制不佳的2型糖尿病患者,随机分为两组,每组30例.在服用原药基础上,利拉鲁肽组联合应用利拉鲁肽,甘精胰岛素组联合应用甘精胰岛素,疗程均为12周.检测治疗前后患者体重指数(BMI)、空腹血糖(FBG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹C肽水平和胰岛素抵抗指数(HOMA-IR),并观察不良反应.结果 治疗后,利拉鲁肽组患者BMI降低,而甘精胰岛素组上升,组间差异非常显著(P＜ 0.01).两组FBG、2hPG及HbA1c均明显下降(P＜0.01),组间无显著差异(P＞0.05).两组空腹C肽均升高,利拉鲁肽组升高幅度大于甘精胰岛素组(P＜0.01).利拉鲁肽组HOMA-IR明显改善,两组间有显著差异(P＜0.01).两组均无严重不良反应发生,利拉鲁肽组发生低血糖1例,甘精胰岛素组3例.结论 利拉鲁肽与甘精胰岛素在控制血糖方面同样有效、安全,利拉鲁肽改善HOMA-IR及减轻体重作用强于甘精胰岛素.
Abstract
AIM To compare the efficacy and safety of liraglutide and insulin glargine in treatment of patients with type 2 diabetes.METHODS Sixty patients with type 2 diabetes without reaching glycemic targets were randomized into two groups (30 patients in each).On the basis of the original drug,the patients in the liraglutide group received liraglutide,while the other patients in the glargine group combined with insulin glargine for 12 weeks.Before and after the treatment,the body mass index (BMI),fasting blood glucose (FBG),2-hour postprandial blood glucose (2hPG),glycosylated hemoglobin A1c (HbA1c),fasting C-peptide,homeostasis model assessment of insulin resistance index (HOMA-IR) and adverse drug reactions were observed.RESULTS After the treatment,the BMI reduced in the liraglutide group but gained in the glargine group.The difference between the two groups was very significant (P ＜ 0.01).The levels of FBG,2hPG and HbA1c decreased in both groups,while no significant difference between groups (P ＞ 0.05).The fasting C-peptide increased in both groups,but improved significantly in the liraglutide group (P ＜ 0.01).HOMA-IR was improved significantly in the liraglutide group after the treatment,but not in the glargine group.There was significant difference between the two groups (P ＜ 0.01).Both drugs were well tolerated.Minor hypoglycemia was less frequent with liraglutide than with insulin glargine (1 vs.3 patients).CONCLUSION Liraglutide and insulin glargine are safe and effective in the control of blood glucose.Liraglutide can produce significant improvement in HOMA-IR and body weight compared with insulin glargine.
关键词
糖尿病,2型/利拉鲁肽/甘精胰岛素Key words
diabetes mellitus, type 2/liraglutide/insulin glargine引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据