Meta-analysis of sodium-glucose cotransporter 2 inhibitors and risk of urinary tract infection and genital infection in patients with type 2 diabetes mellitus
AIM To evaluate the association between the sodium-glucose cotransporter 2(SGLT-2)inhibitors and urinary tract infection and genital infection in patients with type 2 diabetes mellitus(T2DM).METHODS The Chinese Biomedical Literature,Wanfang,CNKI,Cochrane Library and PubMed were searched to collected randomized controlled trial studies about the relationship between SGLT-2 inhibitors and the risk of urinary tract infection and genital infection in patients with T2DM,and the search deadline was December 31,2020.Meta-analysis was conducted by RevMan version 5.4 software.RESULTS Twenty-seven studies enrolling 22 572 participants were selected.The results of meta-analysis showed that SGLT-2 inhibitors did not increase the risk of urinary tract infection in patients with T2DM(OR=1.07,95％CI:0.94 to 1.21,P=0.29).In subgroup analysis of different SGLT-2 inhibitor,intervention cycle,and gender,SGLT-2 inhibitors did not increase the risk of urinary tract infection in patients with T2DM(P＞0.05).SGLT-2 inhibitors significantly increased the risk of genital infection in patients with T2DM(OR=4.14,95％CI:3.45 to 4.97,P＜0.01)compared to the control group.Subgroup analysis showed that SGLT-2 inhibitors were found to significantly increase the risk of genital infection in patients with T2DM for different SGLT-2 inhibitor,intervention cycle,and gender(P＜0.01).CONCLUSION SGLT-2 inhibitors can increase the risk of genital infection in patients with T2DM,but don't increase the risk of urinary tract infection in T2DM patients.
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