Influence of dexamethasone on reversal of rocuronium deep neuromuscular blocking by sugammadex
AIM To study the effect of a single dose of dexamethasone on reversal of rocuronium deep neuromuscular blockade(NMB)by sugammadex.METHODS A total of 80 patients undergoing laparoscopic colon surgeries under general anesthesia were selected,with ASA Ⅰ-Ⅱ,and not taking steroid drug medication.The patients were randomly divided into 2 groups with 40 cases in each group.Before anesthesia induction,the trial group was given dexamethasone 0.15 mg·kg-1,and the control group was given the same amount of chloride sodium injection.The induction and maintenance programs of anesthesia were the same in both groups.Rocuronium was administered intravenously for 5-10 pg·kg-1·min-1 to maintain deep muscle relaxation,and the post-tetanic count(PTC)was maintained at 0-2.After operation,all patients were immediately intravenously injected with sugammadex at a dose of 2 mg·kg-1 when PTC was 1-2.The time for train of four-ratios(TOFR)to reach 0.9,extubation time and occurrence of adverse reactions were recorded.RESULTS The time of TOFR recovery to 0.9,extubation time and post-anesthesia care unit(PACU)residence time were(6.0±0.7),(7.5±0.5)and(36.8±5.8)min in the control group,and(6.0±0.6),(7.7±0.5)and(39.7±6.2)min in the trial group,respectively,with no significant differences between the two groups(P＞0.05).There were no differences in mean arterial pressure and heart rate between the two groups before surgery,at the time of sugammadex administration,and 5 and 10 min after administration(P＞0.05).No adverse reactions occurred in the both groups.CONCLUSION Dexamethasone 0.15 mg· kg-1 has no significant effect on the reversal of deep NMB by sugammadex.
万方数据
维普
