Effect of butylphthalide on oxidative stress indexes and its signaling pathway related factors in patients with acute cerebral infarction
AIM To study the effect of butylphthalide on oxidative stress indicators and its signaling pathway related factors in patients with acute cerebral infarction.METHODS A total of 100 patients with acute cerebral infarction admitted to the hospital from August 2020 to April 2021 were divided into control group and study group by stratified blocked randomization method,with 50 patients in each group.The control group underwent conventional treatment,and the study group was treated with butylphthalide injection(100 mL,iv gtt,bid)for 14 d on the basis of conventional treatment.The two groups were compared in terms of neurological impairment score,oxidative stress indicators,related signaling pathway factors,nerve injury markers,C-reactive protein(CRP)and low-density lipoprotein(LDL)levels,as well as clinical efficacy and safety before and after treatment.RESULTS There were 3 cases in the control group and 2 cases in the study group dropped out during treatment.Finally,47 cases in the control group and 48 cases in the study group were included respectively.After treatment,the level of malondialdehyde in the study group was significantly lower than that in the control group,while superoxide dismutase and glutathione peroxidase were significantly higher than those in the control group(P＜0.05);the Kelch-like ECH-associated protein 1(Keap1)mRNA in the study group was significantly higher than that in the control group,while nuclear factor E2 related factor(Nrf2)and antioxidant response element(ARE)mRNA were significantly lower than those in the control group(P＜0.05).The levels of CRP and LDL in the study group were significantly lower than those in the control group(P＜0.05).The National Institutes of Health Stroke Scale score and the levels of myelin basic protein,neuron-specific enolase,and S100 calcium binding protein B in the study group were significantly lower than those in the control group(P＜0.05).The total effective rate of treatment in the study group was significantly higher than that in the control group(96％vs.81％,P＜0.05),with no statistically significant difference in the total incidence of adverse reactions between the two groups(6％vs.8％,P＞0.05).CONCLUSION Butylphthalide is effective in the treatment of patients with acute cerebral infarction,which may inhibit oxidative stress and relieve neurological damage through affecting the Keap1-Nrf2/ARE signaling pathway,and also has the advantage of regulating lipid metabolism abnormalities and reducing inflammation in the body.
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