Influences of vitamin D2 injection on serum 25-hydroxyvitmin D and immune function in men with vitamin D deficiency aged 80 and over
AIM To evaluate the influences of vitamin D2 injection on serum 25-hydroxyvitmin D(25(OH)D)and immune function in men with vitamin D deficiency aged 80 and over.METHODS A total of 48 men with vitamin D deficiency aged 80 and over were given intramuscular vitamin D2 600 000 IU every month until the serum 25(OH)D reached and over 30 μg·L-1.The levels of serum 25(OH)D2,25(OH)D3,T lymphocyte cells(including CD3+,CD4+,CD8+),B lymphocyte cells(CD19+),and blood calcium and phosphorus were detected before and after treatment.And adverse reactions were observed.RESULTS A total of 40 patients completed the study.It took(6.2±1.4)months for 25(OH)D to reach targeted serum concentration.Compared with those before treatment,the serum levels of 25(OH)D2 after the treatment increased by(27.42±5.47)μg·L-1,25(OH)D3 decreased by(5.25±3.38)μg·L-1,and the total 25(OH)D increased by(22.45±6.15)μg·L-1(all P＜0.01).And the serum levels of CD4+T cells increased by(3.71±6.26)％,CD4+/CD8+increased 0.31±0.93,and CD19+B cell increased by(1.50±3.31)％(all P＜0.05).There were no significant differences in serum CD3+T cells,alanine aminotransferase,blood glucose,creatinine,calcium,and phosphorus before and after the treatment(P＞0.05).No severe adverse drug reactions occurred during the treatment.CONCLUSION Vitamin D2 injection is helpful for increasing serum 25(OH)D2 levels and regulating immune function in men with vitamin D deficiency aged 80 and over.
vitamin D deficiencyaged,80 and over25-hydroxyvitamin D2T-lymphocytes
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