Advancements in targeted therapy for chronic hepatitis B virus infection
Although some progress had been made in the treatment of chronic hepatitis B virus(HBV)infection,current first-line drugs failed to completely eliminate the covalently closed circular DNA(cccDNA)of HBV so as to completely eliminate HBV.Targeted therapy can specifically bind to the target sites,thereby blocking virus invasion,virus transcription,and protein translation,achieving precise treatment.Therefore,this article summarized and reviewed the targets at different stages of the HBV life cycle from the perspectives of targeting virus entry,targeting cccDNA,targeting core protein,targeting hepatitis B surface antigen(HBsAg)release,and targeting viral transcription,with a view to providing ideas for drug development against HBV infection.
hepatitis B virusmolecular targeted therapychronic hepatitis Bdrug development
NETL
NSTL
万方数据
