Research progress of nano-drug delivery system that inhibits signaling pathways in therapy of triple-negative breast cancer
Signaling pathways such as PI3K/AKT/mTOR,Hippo/YAP,Notch,Wnt/β-catenin,and TGF-β play the critical role in the malignant biological behaviors of triple-negative breast cancer(TNBC),including proliferation,invasion,metastasis,and drug resistance.However,conventional chemotherapy drugs often lead to severe adverse reactions,and the utilization of nanotechnology presents a promising solution to this issue.Nano-drug delivery system based on inhibiting signal transduction pathways can carry conventional chemotherapy drugs,block the proliferation of cancer cells,and impede the progression of TNBC.This approach not only offers advantages in targeted therapy but also reduces tissue damage significantly,giving patients more benefits in the future.
triple negative breast neoplasmsWnt signaling pathwaynanoparticle drug delivery systemtherapy
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