苯二氮(卓)类药物对肿瘤患者预后影响的研究进展
Research progress in effects of benzodiazepines on prognosis of tumor patients
刘艳 1王迎斌 2张丽 1曹璐 1张伟 1李欣舫 1郭嘉 1张晶玉2
作者信息
- 1. 兰州大学第二临床医学院,甘肃 兰州 730000;兰州大学第二医院麻醉科,甘肃 兰州 730030
- 2. 兰州大学第二医院麻醉科,甘肃 兰州 730030
- 折叠
摘要
影响肿瘤患者预后的因素较多,且相关机制尚不明确,其中麻醉药物对肿瘤患者的预后也有一定的影响.苯二氮(卓)类药物因其镇静特性被广泛用于肿瘤患者的手术麻醉,已有研究发现地西泮和咪达唑仑可抑制肿瘤细胞增殖、诱导凋亡或坏死.此外,咪达唑仑还能稳定患者围术期状态、提高化疗药物疗效,进而改善患者预后.瑞马唑仑可通过减轻肿瘤患者手术应激反应和免疫抑制作用改善患者预后,其对肿瘤患者预后的直接影响及相关机制需进一步探讨.
Abstract
There are many factors affecting the prognosis of tumor patients,and the related mechanisms are still unclear,among which anesthetics also have certain influence on the prognosis of tumor patients.Benzodiazepines are widely used in surgical anesthesia for tumor patients due to their sedative properties.Previous studies have found that diazepam and midazolam can inhibit the proliferation of tumor cells and induce apoptosis or necrosis.In addition,midazolam can also stabilize the perioperative state of patients,improve the efficacy of chemotherapy drugs,and thus improve the prognosis of patients.Remimazolam can improve the prognosis of tumor patients by alleviating intraoperative stress and immunosuppression.The direct effect of remimazolam on the prognosis of these tumor patients and the related mechanisms need to be further explored.
关键词
苯二氮(卓)类/肿瘤/地西泮/咪达唑仑/瑞马唑仑Key words
benzodiazepines/neoplasms/diazepam/midazolam/remimazolam引用本文复制引用
基金项目
甘肃省自然科学基金(23JRRA0988)
兰州大学第二医院萃英科技创新项目(CY2022-MS-A20)
出版年
2024
NETL
NSTL
万方数据