Attention to latent tuberculosis infection in rheumatic children
Latent tuberculosis infection(LTBI)is a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens without evidence of clinically manifested active tuberculosis.Although LTBI is not contagious,about 5%-15%patients will develop active tuberculosis.Young age and immunosuppression are risk factors for the progression of LTBI to active tuberculosis.Due to the immature immune system,rheumatic disease and anti-rheumatic drugs,children with rheumatic disease are more susceptible to Mycobacterium tuberculosis,and LTBI is also prone to develop into active tuberculosis.China is still a country with a high burden of tuberculosis,more attentions should be paid to LTBI in rheumatic children.Screening for LTBI and preventive anti-tuberculosis treatment can reduce the occurrence of active tuberculosis and ensure the health of rheumatic children.