重视风湿病儿童结核潜伏感染
Attention to latent tuberculosis infection in rheumatic children
隋坤鹏 1张伟1
作者信息
- 1. 电子科技大学医学院附属妇女儿童医院/成都市妇女儿童中心医院儿童风湿免疫科,四川成都 611731
- 折叠
摘要
结核潜伏感染(LTBI)是一种机体对结核分枝杆菌抗原刺激的持续免疫反应状态,未发现活动性结核的临床证据.尽管LTBI不具有传染性,但约5％～15％的患者会发展为活动性结核病,年龄小和免疫抑制状态是LTBI进展为活动性结核病的危险因素.风湿病儿童由于自身免疫系统发育不成熟、风湿病本身及接受抗风湿药治疗等因素,结核分枝杆菌易感性增加,LTBI也容易发展为活动性结核病.我国仍是结核病高负担国家,应重视风湿病儿童LTBI,积极发现LTBI并进行预防性抗结核治疗,以防止活动性结核病发生,保证风湿病儿童健康.
Abstract
Latent tuberculosis infection(LTBI)is a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens without evidence of clinically manifested active tuberculosis.Although LTBI is not contagious,about 5％-15％patients will develop active tuberculosis.Young age and immunosuppression are risk factors for the progression of LTBI to active tuberculosis.Due to the immature immune system,rheumatic disease and anti-rheumatic drugs,children with rheumatic disease are more susceptible to Mycobacterium tuberculosis,and LTBI is also prone to develop into active tuberculosis.China is still a country with a high burden of tuberculosis,more attentions should be paid to LTBI in rheumatic children.Screening for LTBI and preventive anti-tuberculosis treatment can reduce the occurrence of active tuberculosis and ensure the health of rheumatic children.
关键词
风湿性疾病/儿童/分枝杆菌感染/结核Key words
rheumatic diseases/children/mycobacterium infections/tuberculosis引用本文复制引用
基金项目
四川省卫生健康委员会重点研究项目(20ZD019)
成都市技术创新研发项目(2022-YF05-01236-SN)
四川省妇幼保健协会科研课题(2020ZD06)
湖北陈孝平科技发展基金会2021年度免疫性疾病研究槐杞黄专项基金(CXPJJH121002-202149)
成都市妇女儿童中心医院2021年院内科研课题(2022JC06)
出版年
2024
NETL
NSTL
万方数据