首页|重视风湿病儿童结核潜伏感染

重视风湿病儿童结核潜伏感染

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结核潜伏感染(LTBI)是一种机体对结核分枝杆菌抗原刺激的持续免疫反应状态,未发现活动性结核的临床证据。尽管LTBI不具有传染性,但约5%~15%的患者会发展为活动性结核病,年龄小和免疫抑制状态是LTBI进展为活动性结核病的危险因素。风湿病儿童由于自身免疫系统发育不成熟、风湿病本身及接受抗风湿药治疗等因素,结核分枝杆菌易感性增加,LTBI也容易发展为活动性结核病。我国仍是结核病高负担国家,应重视风湿病儿童LTBI,积极发现LTBI并进行预防性抗结核治疗,以防止活动性结核病发生,保证风湿病儿童健康。
Attention to latent tuberculosis infection in rheumatic children
Latent tuberculosis infection(LTBI)is a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens without evidence of clinically manifested active tuberculosis.Although LTBI is not contagious,about 5%-15%patients will develop active tuberculosis.Young age and immunosuppression are risk factors for the progression of LTBI to active tuberculosis.Due to the immature immune system,rheumatic disease and anti-rheumatic drugs,children with rheumatic disease are more susceptible to Mycobacterium tuberculosis,and LTBI is also prone to develop into active tuberculosis.China is still a country with a high burden of tuberculosis,more attentions should be paid to LTBI in rheumatic children.Screening for LTBI and preventive anti-tuberculosis treatment can reduce the occurrence of active tuberculosis and ensure the health of rheumatic children.

rheumatic diseaseschildrenmycobacterium infectionstuberculosis

隋坤鹏、张伟

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电子科技大学医学院附属妇女儿童医院/成都市妇女儿童中心医院儿童风湿免疫科,四川成都 611731

风湿性疾病 儿童 分枝杆菌感染 结核

四川省卫生健康委员会重点研究项目成都市技术创新研发项目四川省妇幼保健协会科研课题湖北陈孝平科技发展基金会2021年度免疫性疾病研究槐杞黄专项基金成都市妇女儿童中心医院2021年院内科研课题

20ZD0192022-YF05-01236-SN2020ZD06CXPJJH121002-2021492022JC06

2024

中国新药与临床杂志
中国药学会 上海市食品药品监督管理局科技情报研究所

中国新药与临床杂志

CSTPCD北大核心
影响因子:0.967
ISSN:1007-7669
年,卷(期):2024.43(6)
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