Application of remimazolam in elderly patients undergoing painless gastro-intestinal endoscopy
AIM To evaluate the effects of remimazolam on painless gastroenteroscopy in elderly patients.METHODS The aged patients scheduled for painless gastroenteroscopy were enrolled and randomly divided into 2 groups.The anesthesia induction regimen of the control group was sufentanil 0.1 μg·kg-1+propofol 1.5 mg·kg-1,and the additional dose of propofol was 0.5 mg·kg-1 each time during the examination.The administration regimen of the experimental group was sufentanil 0.1 μg·kg-1+remimazolam 0.15 mg·kg-1 induction,and each additional dose of remimazolam was 1/3 of the first dose during the examination.Heart rate,respiratory rate,mean arterial pressure,and blood oxygen saturation during anesthesia were recorded.The time of induction,recovery and exit,and adverse reactions such as injection pain,hypoxemia and hypotension were observed.RESULTS A total of 441 patients were included in the analysis,225 in the control group and 116 in the experimental group.Compared with the control group,the mean arterial pressure of the experimental group was higher than that of the control group at 5 and 10 min after administration,and the difference was significant(P＜0.05).The induction,recovery and exit time of the experimental group were(41.8±4.3)s,(5.7±4.4)and(10.2±6.5)min,and those in the control group were(32.6±2.7)s,(6.6±3.9)and(12.9±7.4)min,respectively.The induction time of the experimental group was longer than that of the control group,and the recovery and exit time of the control group were shorter,with significant differences(P＜0.05).Compared with the control group,the incidence of injection pain(54.2％vs.2.3％),hypotension(16.4％vs.6.9％)and hypoxemia(19.6％vs.14.8％)in the experimental groups was significantly reduced(P＜0.05).CONCLUSION Remimazolam is safe and effective for painless gastroenteroscopy in elderly patients,and has the advantages of fast recovery and low incidence of adverse reactions.
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