Research progress on mechanism of aspirin in preventing preeclampsia and drug related gene polymorphism
Preeclampsia is a common hypertensive disorder of pregnancy,which seriously endangers the health of mothers and infants.The early application of low-dose aspirin can effectively prevent preeclampsia,and effectively reduce the probability of hemolysis,elevated liver function and low platelet count syndrome,placental abruption,and fetal distress.In recent years,with the deepening of research,more experimental evidences show that there is a correlation between gene polymorphisms and aspirin resistance.Because some patients have gene polymorphisms,the expected therapeutic effect cannot be achieved.This paper reviewed the research progress of precision medication of aspirin in high-risk pregnant women with preeclampsia,in order to guide the medication of aspirin in special groups such as pregnant women with preeclampsia and improve pregnancy outcomes.
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